Inter-chromosomal gene regulation in the mammalian cell nucleus

被引:44
作者
de Laat, Wouter [1 ]
Grosveld, Frank [1 ]
机构
[1] Erasmus MC, Dept Cell Biol, NL-3015 GE Rotterdam, Netherlands
关键词
D O I
10.1016/j.gde.2007.07.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cellular phenotypes can critically rely on mono-allelic gene expression. Recent studies suggest that in mammalian cells inter-chromosomal DNA interactions may mediate the decision which allele to activate and which to silence. Here, these findings are discussed in the context of knowledge on gene competition, chromatin dynamics, and nuclear organization. We argue that data obtained by 4C technology strongly support the idea that chromatin folds according to self-organizing principles. In this concept, the nuclear positioning of a given locus is probabilistic as it also depends on the properties of neighbouring DNA segments and, by extrapolation, the whole chromosome. The linear distribution of repetitive DNA sequences and of active and inactive DNA regions is important for the folding and relative positioning of chromosomes. This stochastic concept of nuclear organization predicts that tissue-specific interactions between two selected loci present on different chromosomes will be rare.
引用
收藏
页码:456 / 464
页数:9
相关论文
共 45 条
[31]   Spatial proximity of translocation-prone gene loci in human lymphomas [J].
Roix, JJ ;
McQueen, PG ;
Munson, PJ ;
Parada, LA ;
Misteli, T .
NATURE GENETICS, 2003, 34 (03) :287-291
[32]  
Sabatino DE, 1998, MOL CELL BIOL, V18, P6634, DOI 10.1128/MCB.18.11.6634
[33]   Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse [J].
Serizawa, S ;
Miyamichi, K ;
Nakatani, H ;
Suzuki, M ;
Saito, M ;
Yoshihara, Y ;
Sakano, H .
SCIENCE, 2003, 302 (5653) :2088-2094
[34]   One neuron-one receptor rule in the mouse olfactory system [J].
Serizawa, SU ;
Miyamichi, K ;
Sakano, H .
TRENDS IN GENETICS, 2004, 20 (12) :648-653
[35]   Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence [J].
Shopland, Lindsay S. ;
Lynch, Christopher R. ;
Peterson, Kevin A. ;
Thornton, Kathleen ;
Kepper, Nick ;
von Hase, Johann ;
Stein, Stefan ;
Vincent, Sarah ;
Molloy, Kelly R. ;
Kreth, Gregor ;
Cremer, Christoph ;
Bult, Carol J. ;
O'Brien, Timothy P. .
JOURNAL OF CELL BIOLOGY, 2006, 174 (01) :27-38
[36]   Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C) [J].
Simonis, Marieke ;
Klous, Petra ;
Splinter, Erik ;
Moshkin, Yuri ;
Willemsen, Rob ;
de Wit, Elzo ;
van Steensel, Bas ;
de Laat, Wouter .
NATURE GENETICS, 2006, 38 (11) :1348-1354
[37]   Interchromosomal associations between alternatively expressed loci [J].
Spilianakis, CG ;
Lalioti, MD ;
Town, T ;
Lee, GR ;
Flavell, RA .
NATURE, 2005, 435 (7042) :637-645
[38]   Genome architecture, rearrangements and genomic disorders [J].
Stankiewicz, P ;
Lupski, JR .
TRENDS IN GENETICS, 2002, 18 (02) :74-82
[39]   The radial positioning of chromatin is not inherited through mitosis but is established de novo in early G1 [J].
Thomson, I ;
Gilchrist, S ;
Bickmore, WA ;
Chubb, JR .
CURRENT BIOLOGY, 2004, 14 (02) :166-172
[40]   Looping and interaction between hypersensitive sites in the active β-globin locus [J].
Tolhuis, B ;
Palstra, RJ ;
Splinter, E ;
Grosveld, F ;
de Laat, W .
MOLECULAR CELL, 2002, 10 (06) :1453-1465