Synthesis of New [(2S)-N-(p-Tolylsulfonyl)-2-Pyrrolidinyl]Propyl 2,3,4-Tri-O-Acetyl- and 2,3,4-Tri-O-Benzyl-β-L-Fucopyranosides

被引：0

作者：

Joselice e Silva, Maria ^{[1
]}

Srivastava, Rajendra M. ^{[1
]}

Doboszewski, Bogdan ^{[2
]}

Cottier, Louis ^{[3
]}

Sinou, Denis ^{[3
]}

机构：

[1] Univ Fed Pernambuco, Dept Quim Fundamental, BR-50740540 Recife, PE, Brazil

[2] Univ Fed Pernambuco, Dept Quim, BR-50740540 Recife, PE, Brazil

[3] Univ Lyon 1, Lab Synth Asymetr, CNRS UMR 5181, ESCPE Lyon, F-69622 Villeurbanne, France

来源：

HETEROCYCLIC COMMUNICATIONS | 2010年 / 16卷 / 2-3期

关键词：

L-Proline; delta-amino alcohol; O-alpha-L-fucosyltrichloroacetimidate; beta-L-fucopyranoside; glycosylation; OLIGOSACCHARIDE SYNTHESIS; GLYCOSYLATION; TRICHLOROACETIMIDATE; PYRROLIDINE; CLEAVAGE;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of two new glycoheterocyclic compounds, [(2S)-N-(p-tolylsulfonyl)-2-pyrrolidinyl]propyl 2,3,4-tri-O-acetyl- and 2,3,4-tri-O-benzyl-beta-L-fucopyranosides 1a and 1b, starting from 6-amino alcohol (-)-[(2S)-N-(p-tolylsulfonyl)-2-pyrrolidinyl]propan-1-ol 2 and O-alpha-L-fucosyltrichloroacetimidates 3a or 3b as glycosyl donor is described. Hitherto delta-aminoalcohol 2 was synthesized from L-proline without any racemization during its preparation.

引用

页码：105 / 111

页数：7

共 20 条

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