Astrocytes and Inflammasome: A Possible Crosstalk in Neurological Diseases

被引：7

作者：

Nourbakhsh, Fahimeh ^{[1
]}

Read, Morgayn, I ^{[2
]}

Barreto, George E. ^{[3
,4
]}

Sahebkar, Amirhossein ^{[5
,6
,7
,8
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Med Toxicol Res Ctr, Mashhad, Razavi Khorasan, Iran

[2] Univ Otago, Dept Pharmacol, Sch Med Sci, Dunedin, New Zealand

[3] Univ Limerick, Dept Biol Sci, Limerick, Ireland

[4] Univ Limerick, Hlth Res Inst, Limerick, Ireland

[5] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran

[7] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland

[8] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran

来源：

CURRENT MEDICINAL CHEMISTRY | 2021年 / 28卷 / 24期

关键词：

Astrocytes; inflammasome; neurological diseases; inflammation; signaling; NOD-like receptors; NF-KAPPA-B; CENTRAL-NERVOUS-SYSTEM; TRAUMATIC BRAIN-INJURY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; SPINAL-CORD-INJURY; NLRP3; INFLAMMASOME; MULTIPLE-SCLEROSIS; TRANSGENIC INHIBITION; REACTIVE ASTROCYTES; SIGNALING PATHWAY;

D O I：

10.2174/0929867328666210301105422

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammasome research has primarily focused on neurological tissue, particu-larly on damaged tissue. Most current neurological literature involves in vivo and in vitro studies utilizing astroglia, as astroglia express the cytoskeletal glial fibrillary acidic pro-tein (GFAP), which is used as a hallmark of neuropathological disorders. Research suggests that astrocytes respond to all forms of neurological damage or disease through reactive astrogliosis. Additionally, there is a consensus among scientists that inflamma-somes play an important role in neuroinflammation. This review focuses on the latest de-velopments in inflammasome biology, describing the current understanding of how in-flammasomes can be triggered in the brain and summarizing the literature on the rele-vance of inflammasome NLR in prevalent neurological diseases.

引用

页码：4972 / 4994

页数：23

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