Astrocytes and Inflammasome: A Possible Crosstalk in Neurological Diseases

Inflammasome research has primarily focused on neurological tissue, particu-larly on damaged tissue. Most current neurological literature involves in vivo and in vitro studies utilizing astroglia, as astroglia express the cytoskeletal glial fibrillary acidic pro-tein (GFAP), which is used as a hallmark of neuropathological disorders. Research suggests that astrocytes respond to all forms of neurological damage or disease through reactive astrogliosis. Additionally, there is a consensus among scientists that inflamma-somes play an important role in neuroinflammation. This review focuses on the latest de-velopments in inflammasome biology, describing the current understanding of how in-flammasomes can be triggered in the brain and summarizing the literature on the rele-vance of inflammasome NLR in prevalent neurological diseases.