Novel insight into the pathobiology of abdominal aortic aneurysm and potential future treatment concepts

被引：42
作者：
Diehm, Nicolas
Dick, Florian
Schaffner, Thomas
Schmidli, Juerg
Kalka, Christoph
Di Santo, Stefano
Voelzmann, Jan
Baumgartner, Iris
机构：
[1] Univ Hosp Bern, Clin & Intervent Angiol, CH-3010 Bern, Switzerland
[2] Univ Hosp Bern, Swiss Cardiovasc Surg, Div Clin Intervent Angiol, CH-3010 Bern, Switzerland
[3] Univ Hosp Bern, Swiss Cardiovasc Surg, Dept Cardiovasc Surg, CH-3010 Bern, Switzerland
[4] Univ Hosp Bern, Swiss Cardiovasc Surg, Dept Pathol, CH-3010 Bern, Switzerland
来源：
PROGRESS IN CARDIOVASCULAR DISEASES | 2007年 / 50卷 / 03期
关键词：
NITRIC-OXIDE SYNTHASE; ANGIOTENSIN-II; RISK-FACTORS; VITAMIN-E; MATRIX METALLOPROTEINASES; SIMVASTATIN SUPPRESSES; PREVALENCE; EXPANSION; DISEASE; ATHEROSCLEROSIS;
D O I：
10.1016/j.pcad.2007.05.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The patient with abdominal aortic aneurysm (AAA) commonly is a nondiabetic, white man with a history of smoking. Moreover, AAA represents a leading cause of death in elderly men in Western countries. The purpose of this manuscript is to review current evidence as to the pathobiology of AAA as well as potential future drug targets to prevent progression of AAA. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：209 / 217
页数：9
相关论文
共 84 条
[1]   Altered patterns of gene expression distinguishing ascending aortic aneurysms from abdominal aortic aneurysms: Complementary DNA expression profiling in the molecular characterization of aortic disease [J].
Absi, TS ;
Sundt, TM ;
Tung, WS ;
Moon, M ;
Lee, JK ;
Damiano, RR ;
Thompson, RW .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2003, 126 (02) :344-357
[2]   Nitric oxide synthases: structure, function and inhibition [J].
Alderton, WK ;
Cooper, CE ;
Knowles, RG .
BIOCHEMICAL JOURNAL, 2001, 357 (03) :593-615
[3]   Reduced aortic wall stress in diabetes mellitus [J].
Astrand, H. ;
Ryden-Ahlgren, A. ;
Sundkvist, G. ;
Sandgren, T. ;
Lanne, T. .
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2007, 33 (05) :592-598
[4]  
BAHASHI JP, 2006, SCIENCE, V312, P117
[5]   Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high-frequency ultrasonography [J].
Barisione, Chiara ;
Charnigo, Richard ;
Howatt, Deborah A. ;
Moorleghen, Jessica J. ;
Rateri, Debra L. ;
Daugherty, Alan .
JOURNAL OF VASCULAR SURGERY, 2006, 44 (02) :372-376
[6]   HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages [J].
Bellosta, S ;
Via, D ;
Canavesi, M ;
Pfister, P ;
Fumagalli, R ;
Paoletti, R ;
Bernini, F .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (11) :1671-1678
[7]   RUPTURED ABDOMINAL AORTIC-ANEURYSM - A POPULATION-BASED STUDY [J].
BENGTSSON, H ;
BERGQVIST, D .
JOURNAL OF VASCULAR SURGERY, 1993, 18 (01) :74-80
[8]   Incidence and prevalence of abdominal aortic aneurysms, estimated by necropsy studies and population screening by ultrasound [J].
Bengtsson, H ;
Sonesson, B ;
Bergqvist, D .
ABDOMINAL AORTIC ANEURYSM: GENETICS, PATHOPHYSIOLOGY, AND MOLECULAR BIOLOGY, 1996, 800 :1-24
[9]   Abdominal aortic aneurysm expansion - Risk factors and time intervals for surveillance [J].
Brady, AR ;
Thompson, SG ;
Fowkes, FGR ;
Greenhalgh, RM ;
Powell, JT .
CIRCULATION, 2004, 110 (01) :16-21
[10]   Selective management of abdominal aortic aneurysms smaller than 5.0 cm in a prospective sizing program with gender-specific analysis [J].
Brown, PM ;
Sobolev, B ;
Zelt, DT .
JOURNAL OF VASCULAR SURGERY, 2003, 38 (04) :762-765
123456789