Self-administration of drugs in animals and humans as a model and an investigative tool

被引:189
作者
Panlilio, Leigh V. [1 ]
Goldberg, Steven R. [1 ]
机构
[1] Natl Inst Drug Abuse, Preclin Pharmacol Sect, Behav Neurosci Res Branch, Intramural Res Program,NIH DHHS, Baltimore, MD 21224 USA
关键词
abuse liability; addiction; animal models; escalation; operant behavior; reinforcement; self-administration; translational research;
D O I
10.1111/j.1360-0443.2007.02011.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Aims To review briefly the methods, assumptions, models, accomplishments, drawbacks and future directions of research using drug self-administration in animals and humans. Background The use of drug self-administration to study addiction is based on the assumption that drugs reinforce the behavior that results in their delivery. A wide range of drug self-administration techniques have been developed to model specific aspects of addiction. These techniques are highly amenable to being combined with a wide variety of neuroscience techniques. Conclusions The identification of drug use as behavior that is reinforced by drugs has contributed greatly to the understanding and treatment of addiction. As part of a program of pre-clinical research that also involves screening with a variety of simpler behavioral techniques, drug self-administration procedures can provide an important last step in testing potential treatments for addiction. There is currently a concerted effort to develop self-administration procedures that model the extreme nature of the behavior engendered by addiction. As advances continue to be made in neuroscience techniques, self-administration should continue to provide a means of applying these techniques within a sophisticated and valid model of human drug addiction.
引用
收藏
页码:1863 / 1870
页数:8
相关论文
共 40 条
[1]   VARIATIONS IN THE SENSITIVITY OF INSTRUMENTAL RESPONDING TO REINFORCER DEVALUATION [J].
ADAMS, CD .
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1982, 34 (MAY) :77-98
[2]  
ADLER MW, 1995, DRUG ALCOHOL DEPEN, V37, P167
[3]   Persistent increase in the motivation to take heroin in rats with a history of drug escalation [J].
Ahmed, SH ;
Walker, JR ;
Koob, GF .
NEUROPSYCHOPHARMACOLOGY, 2000, 22 (04) :413-421
[4]   A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement [J].
Arnold, JM ;
Roberts, DCS .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1997, 57 (03) :441-447
[5]   FIXED-INTERVAL SCHEDULE OF COCAINE REINFORCEMENT - EFFECT OF DOSE AND INFUSION DURATION [J].
BALSTER, RL ;
SCHUSTER, CR .
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR, 1973, 20 (01) :119-129
[6]   BEHAVIORAL ECONOMICS - A NOVEL EXPERIMENTAL APPROACH TO THE STUDY OF DRUG-DEPENDENCE [J].
BICKEL, WK ;
DEGRANDPRE, RJ ;
HIGGINS, ST .
DRUG AND ALCOHOL DEPENDENCE, 1993, 33 (02) :173-192
[7]   TOXICITY ASSOCIATED WITH LONG-TERM INTRAVENOUS HEROIN AND COCAINE SELF-ADMINISTRATION IN THE RAT [J].
BOZARTH, MA ;
WISE, RA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 254 (01) :81-83
[8]   SELF-ADMINISTRATION OF PSYCHOACTIVE SUBSTANCES BY MONKEY - A MEASURE OF PSYCHOLOGICAL DEPENDENCE [J].
DENEAU, G ;
YANAGITA, T ;
SEEVERS, MH .
PSYCHOPHARMACOLOGIA, 1969, 16 (01) :30-&
[9]   Evidence for addiction-like behavior in the rat [J].
Deroche-Gamonet, V ;
Belin, D ;
Piazza, PV .
SCIENCE, 2004, 305 (5686) :1014-1017
[10]   Alcohol seeking by rats: Action or habit? [J].
Dickinson, A ;
Wood, N ;
Smith, JW .
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 2002, 55 (04) :331-348