Microvessel density as a prognostic factor in esophageal squamous cell cancer patients A meta-analysis

被引：18

作者：

Ma, Guangzhi ^{[1
,2
]}

Zhang, Jing ^{[3
]}

Jiang, Hai ^{[4
]}

Zhang, Nannan ^{[3
]}

Zhu, Yunjie ^{[2
]}

Deng, Yunfu ^{[1
]}

Zhou, Qinghua ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Lung Canc Ctr, Chengdu, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Thorac Surg, Chengdu, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China

[4] Sichuan Univ, West China Hosp, Dept Orthoped Surg, Chengdu, Sichuan, Peoples R China

来源：

MEDICINE | 2017年 / 96卷 / 29期

基金：

中国国家自然科学基金;

关键词：

esophageal squamous cell cancer; meta-analysis; microvessel density; prognostic factor; ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS; COLORECTAL-CANCER; FACTOR EXPRESSION; CARCINOMA; SURVIVAL; METASTASIS; PREDICTS; LYMPHANGIOGENESIS; STATISTICS;

D O I：

10.1097/MD.0000000000007600

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: To date, literature has emerged that shows contradictory results about the prognostic role of microvessel density (MVD) in esophageal squamous cell cancer (ESCC). The aim of the study set out to evaluate the correlation between MVD and the prognosis of ESCC. Methods: Identified publications from various databases were obtained and reviewed. A meta-analysis was performed to evaluate the prognostic role of MVD among ESCC patients. Results: A total of 11 eligible studies containing 891 ESCC cases were included in the meta-analysis. The pooled hazard ratio for overall survival was 2.39 (95% confidence interval 1.92-2.96, P<.001). Heterogeneity among the studies was not significant, and publication bias was not found. Subgroup analyses were also performed on different issues, such as districts, antibodies, and median age. Conclusion: High MVD is a prognostic factor among ESCC that indicated worse prognosis in these patients. More studies are needed, and through abundant evidence, the topic could be re-evaluated by then.

引用

页数：6

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