Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice

被引:3
作者
Juarez, Yamila Raquel [1 ]
Quiroga, Sofia [1 ]
Prochnik, Andres [1 ]
Wald, Miriam [1 ]
Tellechea, Mariana Lorena [2 ]
Genaro, Ana Maria [1 ,3 ]
Burgueno, Adriana Laura [1 ]
机构
[1] Pontificia Univ Catolica Argentina, Consejo Nacl Invest Cient & Tecn CONICET, Inst Invest Biomed, Av Alicia Moreau de Justo 1600,Piso 3,C1107AFF, Buenos Aires, DF, Argentina
[2] Hosp Ninos Dr Ricardo Gutierrez, CONICET FEI, Div Endocrinol, Ctr Invest Endocrinol Dr Cesar Bergada, Gallo 1330,C1425EFD, Buenos Aires, DF, Argentina
[3] Univ Buenos Aires, Fac Med, Dept Farmacol, Paraguay 2151 Piso 15,C1121ABG, Buenos Aires, DF, Argentina
关键词
Prenatal stress; obesity; metabolism; gene expression; INTRAUTERINE GROWTH-RESTRICTION; CATCH-UP GROWTH; GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; SLEEP FRAGMENTATION; INDUCED OBESITY; BIRTH-WEIGHT; SEX; INFLAMMATION;
D O I
10.1017/S2040174420000987
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Prenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked with the development of obesity. The main goal of this study was to analyze the impact of the exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21. Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of sirtuin-1. When these animals were fed a HFD, we observed a rise in glucose and insulin levels and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1 beta. Although females proved to be more resilient to PS consequences, when they were fed a HFD, they showed significant metabolic impairment. In addition to the changes observed in males, females also presented an increase in body weight and adiposity and a rise in cholesterol levels.
引用
收藏
页码:721 / 730
页数:10
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