A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex

被引：183

作者：

de Vries, Saskia E. J. ^{[1
]}

Lecoq, Jerome A. ^{[1
]}

Buice, Michael A. ^{[1
]}

Groblewski, Peter A. ^{[1
]}

Ocker, Gabriel K. ^{[1
]}

Oliver, Michael ^{[1
]}

Feng, David ^{[1
]}

Cain, Nicholas ^{[1
]}

Ledochowitsch, Peter ^{[1
]}

Millman, Daniel ^{[1
]}

Roll, Kate ^{[1
]}

Garrett, Marina ^{[1
]}

Keenan, Tom ^{[1
]}

Kuan, Leonard ^{[1
]}

Mihalas, Stefan ^{[1
]}

Olsen, Shawn ^{[1
]}

Thompson, Carol ^{[1
]}

Wakeman, Wayne ^{[1
]}

Waters, Jack ^{[1
]}

Williams, Derric ^{[1
]}

Barber, Chris ^{[1
]}

Berbesque, Nathan ^{[1
]}

Blanchard, Brandon ^{[1
]}

Bowles, Nicholas ^{[1
]}

Caldejonl, Shiella D. ^{[1
]}

Casal, Linzy ^{[1
]}

Cho, Andrew ^{[1
]}

Cross, Sissy ^{[1
]}

Dang, Chinh ^{[1
]}

Dolbeare, Tim ^{[1
]}

Edwards, Melise ^{[1
]}

Galbraith, John ^{[1
]}

Gaudreault, Nathalie ^{[1
]}

Gilbert, Terri L. ^{[1
]}

Griffin, Fiona ^{[1
]}

Hargrave, Perry ^{[1
]}

Howard, Robert ^{[1
]}

Huang, Lawrence ^{[1
]}

Jewell, Sean ^{[2
]}

Keller, Nika ^{[1
]}

Knoblich, Ulf ^{[1
]}

Larkin, Josh D. ^{[1
]}

Larsen, Rachael ^{[1
]}

Lau, Chris ^{[1
]}

Lee, Eric ^{[1
]}

Lee, Felix ^{[1
]}

Leon, Arielle ^{[1
]}

Li, Lu ^{[1
]}

Long, Fuhui ^{[1
]}

Luviano, Jennifer ^{[1
]}

机构：

[1] Allen Inst Brain Sci, Seattle, WA 98109 USA

[2] Univ Washington, Dept Stat, Seattle, WA 98195 USA

[3] Univ Washington, Dept Appl Math, Seattle, WA 98195 USA

[4] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

来源：

NATURE NEUROSCIENCE | 2020年 / 23卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

RECEPTIVE-FIELDS; NATURAL IMAGES; GABAERGIC NEURONS; CRE-RECOMBINASE; DRIVER LINES; STIMULI; REPRESENTATION; RESPONSES; SPECIALIZATION; ARCHITECTURE;

D O I：

10.1038/s41593-019-0550-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By comparing neural responses to diverse visual stimuli measured with a standardized two-photon imaging pipeline, the authors reveal response specializations within the mouse visual cortex. To understand how the brain processes sensory information to guide behavior, we must know how stimulus representations are transformed throughout the visual cortex. Here we report an open, large-scale physiological survey of activity in the awake mouse visual cortex: the Allen Brain Observatory Visual Coding dataset. This publicly available dataset includes the cortical activity of nearly 60,000 neurons from six visual areas, four layers, and 12 transgenic mouse lines in a total of 243 adult mice, in response to a systematic set of visual stimuli. We classify neurons on the basis of joint reliabilities to multiple stimuli and validate this functional classification with models of visual responses. While most classes are characterized by responses to specific subsets of the stimuli, the largest class is not reliably responsive to any of the stimuli and becomes progressively larger in higher visual areas. These classes reveal a functional organization wherein putative dorsal areas show specialization for visual motion signals.

引用

页码：138 / +

页数：31

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