Myocardial infarction is a complication of factor H-associated atypical HUS

被引：42

作者：

Sallee, Marion ^{[1
]}

Daniel, Laurent ^{[2
]}

Piercecchi, Marie-Dominique ^{[3
]}

Jaubert, Dominique ^{[1
]}

Fremeaux-Bacchi, Veronique ^{[4
]}

Berland, Yvon ^{[1
]}

Burtey, Stephane ^{[1
]}

机构：

[1] Univ Med, Ctr Nephrol & Transplantat Renale, AP HM, Hop Concept, Marseille, France

[2] Hop Enfants La Timone, AP HM, Serv Anat Pathol, Marseille, France

[3] Hop Enfants La Timone, AP HM, Serv Med Legale & Droit Med, Marseille, France

[4] Hop Georges Pompidou, AP HP, Serv Immunol, Paris, France

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2010年 / 25卷 / 06期

关键词：

atypical haemolytic-uraemic syndrome; coronary thrombotic microangiopathy; factor H mutation; sudden death; HEMOLYTIC-UREMIC SYNDROME; THROMBOTIC THROMBOCYTOPENIC PURPURA; CARDIAC-TAMPONADE; MUTATIONS; CARDIOMYOPATHY; FAILURE;

D O I：

10.1093/ndt/gfq160

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Cardiac complications are frequently seen in thrombotic thrombocytopaenic purpura related to ADAMTS13 deficiency. We describe the case of a 43-year-old woman who was diagnosed with an atypical haemolytic uraemic syndrome (aHUS) associated with a pathogenic mutation in the factor H gene (C623S). After 15 days of treatment, she suffered a sudden cardiac arrest and died despite intensive resuscitation attempts. She showed only one cardiovascular risk factor, hypercholesterolaemia. Her sudden death was secondary to cardiac infarction related to a coronary thrombotic microangiopathy. This is the first case of aHUS related to a mutation in the factor H gene associated with cardiac microangiopathy. This case emphasizes the need to screen for cardiac complication during the treatment of aHUS.

引用

页码：2028 / 2032

页数：5

共 26 条

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