Automated three-dimensional quantification of myocardial perfusion and brain SPECT

被引：32

作者：

Slomka, PJ ^{[1
]}

Radau, P ^{[1
]}

Hurwitz, GA ^{[1
]}

Dey, D ^{[1
]}

机构：

[1] Univ Western Ontario, London Hlth Sci Ctr, Dept Diagnost Radiol & Nucl Med, London, ON N6A 4G5, Canada

来源：

COMPUTERIZED MEDICAL IMAGING AND GRAPHICS | 2001年 / 25卷 / 02期

关键词：

myocardial perfusion; Alzheimer's disease; nuclear medicine; SPECT; image registration; image quantification; automated analysis; computer aided diagnosis;

D O I：

10.1016/S0895-6111(00)00044-6

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

To allow automated and objective reading of nuclear medicine tomography, we have developed a set of tools for clinical analysis of myocardial perfusion tomography (PERFIT) and Brain SPECT/PET (BRASS). We exploit algorithms for image registration and use three-dimensional (3D) "normal models' for individual patient comparisons to composite datasets on a "voxel-by-voxel basis" in order to automatically determine the statistically significant abnormalities. A multistage, 3D iterative inter-subject registration of patient images to normal templates is applied, including automated masking of the external activity before final fit. In separate projects, the software has been applied to the analysis of myocardial perfusion SPECT, as well as brain SPECT and PET data. Automatic reading was consistent with visual analysis; it can be applied to the whole spectrum of clinical images, and aid physicians in the daily interpretation of tomographic nuclear medicine images. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：153 / 164

页数：12

共 18 条

[1]

ALPERT NM, 1990, J NUCL MED, V31, P1717

[2]

BOIRE J, 1989, P 11 ANN INT C IEEE, P578

[3] COMPARING FUNCTIONAL (PET) IMAGES - THE ASSESSMENT OF SIGNIFICANT CHANGE [J].

FRISTON, KJ ;

FRITH, CD ;

LIDDLE, PF ;

FRACKOWIAK, RSJ .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1991, 11 (04) :690-699

[4] TECHNICAL ASPECTS OF MYOCARDIAL SPECT IMAGING WITH TC-99M SESTAMIBI [J].

GARCIA, EV ;

COOKE, CD ;

VANTRAIN, KF ;

FOLKS, R ;

PEIFER, J ;

DEPUEY, EG ;

MADDAHI, J ;

ALAZRAKI, N ;

GALT, J ;

EZQUERRA, N ;

ZIFFER, J ;

AREEDA, J ;

BERMAN, DS .

AMERICAN JOURNAL OF CARDIOLOGY, 1990, 66 (13) :E23-E31

[5] An automatic approach to the analysis, quantitation and review of perfusion and function from myocardial perfusion SPECT images [J].

Germano, G ;

Kavanagh, PB ;

Berman, DS .

INTERNATIONAL JOURNAL OF CARDIAC IMAGING, 1997, 13 (04) :337-346

[6]

HURWITZ GA, 1995, J NUCL MED, V36, P914

[7] Single and multimodal subvoxel registration of dissimilar medical images using robust similarity measures [J].

Nikou, C ;

Heitz, F ;

Armspach, JP ;

Namer, IJ .

MEDICAL IMAGING 1998: IMAGE PROCESSING, PTS 1 AND 2, 1998, 3338 :167-178

[8]

RADAU PE, 2000, IN PRESS J NUCL MED

[9]

RADAU PE, 2000, SPIE MED IMAG, V3979, P372

[10]

ROBB RA, 1992, P 13 16 OCT 1992 C S

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