Synthesis of double hydrophilic graft copolymer containing poly(ethylene glycol) and poly(methacrylic acid) side chains via successive ATRP

被引：39

作者：

Gu, Lina ^{[1
,2
]}

Shen, Zhong ^{[1
,2
]}

Feng, Chun ^{[1
,2
]}

Li, Yaogong ^{[1
,2
]}

Lu, Guolin ^{[1
,2
]}

Huang, Xiaoyu ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Polymer Mat, Shanghai 200032, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2008年 / 46卷 / 12期

关键词：

atom transfer radical polymerization (ATRP); double hydrophilic; graft copolymers; synthesis;

D O I：

10.1002/pola.22748

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A well-defined double hydrophilic graft copolymer, with polyacrylate as backbone, hydrophilic poly(ethylene glycol) and poly(methacrylic acid) as side chains, was synthesized via successive atom transfer radical polymerization followed by the selective hydrolysis of poly(methoxymethyl methacrylate) side chains. The grafting-through strategy was first used to prepare poly[poly(ethylene glycol) methyl ether acrylate] comb copolymer. The obtained comb copolymer was transformed into macroinitiator by reacting with lithium diisopropylamine and 2-bromopropionyl chloride. Afterwards, grafting-from route was employed for the synthesis of poly[poly(ethylene glycol) methyl ether acrylatel-g-poly(methoxymethyl methacrylate) amphiphilic graft copolymer. The molecular weight distribution of this amphiphilic graft copolymer was narrow. Poly(methoxymethyl methacrylate) side chains were connected to polyacrylate backbone through stable C-C bonds instead of ester connections. The final product, poly[poly(ethylene glycol) methyl ether acrylatel-g-poly(methacrylate acid), was obtained by selective hydrolysis of poly(methoxymethyl methaerylate) side chains under mild conditions without affecting the polyacrylate backbone. This double hydrophilic graft copolymer was found be stimuli-responsive to pH and ionic strength. (c) 2008 Wiley Periodicals, Inc.

引用

页码：4056 / 4069

页数：14

共 65 条

[41] Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile ß-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells [J].