Aberrant expression of PlncRNA-1 and TUG1: potential biomarkers for gastric cancer diagnosis and clinically monitoring cancer progression

被引：44

作者：

Baratieh, Zohreh ^{[1
]}

Khalaj, Zahra ^{[1
]}

Honardoost, Mohammad Amin ^{[1
,2
]}

Emadi-Baygi, Modjtaba ^{[3
,4
]}

Khanahmad, Hossein ^{[1
]}

Salehi, Mansoor ^{[1
]}

Nikpour, Parvaneh ^{[1
,5
]}

机构：

[1] Isfahan Univ Med Sci, Fac Med, Dept Genet & Mol Biol, Esfahan, Iran

[2] Univ Isfahan, Fac Sci, Dept Biol, Div Cellular & Mol Biol, Esfahan, Iran

[3] Shahrekord Univ, Fac Basic Sci, Dept Genet, Shahrekord, Iran

[4] Shahrekord Univ, Res Inst Biotechnol, Shahrekord, Iran

[5] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Esfahan, Iran

来源：

BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 12期

关键词：

FAM83H-AS1; gastric cancer; gene expression; PlncRNA-1; TUG1; NONCODING RNA TUG1; CELL-PROLIFERATION; UP-REGULATION; PROMOTES METASTASIS; DOWN-REGULATION; APOPTOSIS; CARCINOMA; MIGRATION; SURVIVAL;

D O I：

10.2217/bmm-2017-0090

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To evaluate PlncRNA-1, TUG1 and FAM83H-AS1 gene expression and their possible role as a biomarker in gastric cancer (GC) progression. Patients & methods: Long noncoding RNA expressions and clinicopathological characteristics were assessed in 70 paired GC tissues. Furthermore, corresponding data from 318 GC patients were downloaded from The Cancer Genome Atlas database. Results: Expression of PlncRNA-1 and TUG1 were significantly upregulated in GC tumoral tissues, and significantly correlated with clinicopathological characters. However, FAM83H-AS1 showed no consistently differential expression. The expression of these three long noncoding RNAs was significantly higher in The Cancer Genome Atlas tumoral tissues. Conclusion: In conclusion, PlncRNA-1 and TUG1 genes may play a critical role in GC progression and may serve as potential diagnostic biomarkers in GC patients.

引用

页码：1077 / 1090

页数：14

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