Synthesis, antimicrobial, antioxidant, anti-inflammatory, and analgesic activities of some new 3-(2'-thienyl)pyrazole-based heterocycles

被引：34

作者：

Abdel-Wahab, Bakr F. ^{[1
]}

Abdel-Gawad, Hassan ^{[2
]}

Awad, Ghada E. A.

Badria, Farid A. ^{[3
]}

机构：

[1] King Abdulaziz Univ, Fac Sci & Arts, Dept Chem, Khulais Branch, Jeddah, Saudi Arabia

[2] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt

[3] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 07期

关键词：

2-Thienylpyrazoles; Thiazoles; Heterocycles; Antimicrobial; Antioxidant; Analgesic; Anti-inflammatory activities; PYRAZOLE DERIVATIVES; AGENTS;

D O I：

10.1007/s00044-011-9661-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-Phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde was used as a synthon for the synthesis of new thiazole and pyrazoline heterocycles having 2-thienylpyrazole moiety. The antimicrobial, anti-inflammatory, and analgesic activities of the synthesized compounds were evaluated using agar diffusion method, carrageenan-induced paw edema, and writhing assays, respectively. It was found that the majority of the tested compounds exhibited both analgesic and anti-inflammatory activities.

引用

页码：1418 / 1426

页数：9

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