Inflammatory bowel disease

被引:58
作者
Boirivant, M. [1 ]
Cossu, A. [1 ]
机构
[1] Ist Super Sanita, Dept Infect Parasit & Immunemediated Dis, Immunemediated Dis Sect, I-00161 Rome, Italy
关键词
inflammatory bowel disease; management; pathogenesis; therapy; REGULATORY T-CELLS; EVIDENCE-BASED CONSENSUS; GENOME-WIDE ASSOCIATION; POPULATION-BASED COHORT; NECROSIS-FACTOR-ALPHA; GROWTH-FACTOR-BETA; TRANS-RETINOIC ACID; CROHNS-DISEASE; ULCERATIVE-COLITIS; DENDRITIC CELLS;
D O I
10.1111/j.1601-0825.2011.01811.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
This review focuses on the prominent etiological and pathogenetic aspects of inflammatory bowel disease (IBD), with particular attention being paid to the mucosal immune response to commensal micro-organisms in health and disease. Pathogenetic implications for target therapy will also be discussed. The clinical presentation, diagnostic aspects, and currently recommended therapeutic options for the two main types of IBD are also taken into consideration, including manifestations of these conditions in the oral cavity.
引用
收藏
页码:1 / 15
页数:15
相关论文
共 203 条
[1]   Functional consequences of NOD2 (CARD15) mutations [J].
Abraham, Clara ;
Cho, Judy H. .
INFLAMMATORY BOWEL DISEASES, 2006, 12 (07) :641-650
[2]   MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].
Abraham, Clara ;
Cho, Judy H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) :2066-2078
[3]   The interleukin-23 axis in intestinal inflammation [J].
Ahern, Philip P. ;
Izcue, Ana ;
Maloy, Kevin J. ;
Powrie, Fiona .
IMMUNOLOGICAL REVIEWS, 2008, 226 :147-159
[4]   Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells [J].
Ahern, Philip P. ;
Schiering, Chris ;
Buonocore, Sofia ;
McGeachy, Mandy J. ;
Cua, Dan J. ;
Maloy, Kevin J. ;
Powrie, Fiona .
IMMUNITY, 2010, 33 (02) :279-288
[5]   The molecular classification of the clinical manifestations of Crohn's disease [J].
Ahmad, T ;
Armuzzi, A ;
Bunce, M ;
Mulcahy-Hawes, K ;
Marshall, SE ;
Orchard, TR ;
Crawshaw, J ;
Large, O ;
De Silva, A ;
Cook, JT ;
Barnardo, M ;
Cullen, S ;
Welsh, KI ;
Jewell, DP .
GASTROENTEROLOGY, 2002, 122 (04) :854-866
[6]   Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence [J].
Alvarez-Lobos, M ;
Arostegui, JI ;
Sans, M ;
Tassies, D ;
Plaza, S ;
Delgado, S ;
Lacy, AM ;
Pique, JM ;
Yagüe, J ;
Panés, J .
ANNALS OF SURGERY, 2005, 242 (05) :693-700
[7]   Double contrast small-bowel radiography in the preoperative assessment of Crohn's disease: Is it still useful? [J].
Angriman, Imerio ;
Scarpa, Marco ;
Ruffolo, Cesare ;
Pomerri, Fabio ;
Filosa, Teresa ;
Polese, Lino ;
Pagano, Duilio ;
Norberto, Lorenzo ;
D'Amico, Davide F. .
SURGERY TODAY, 2008, 38 (08) :700-704
[8]   Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut [J].
Artis, David .
NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :411-420
[9]   Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation:: Evidence in Crohn disease and experimental colitis in vivo [J].
Atreya, R ;
Mudter, J ;
Finotto, S ;
Müllberg, J ;
Jostock, T ;
Wirtz, S ;
Schütz, M ;
Bartsch, B ;
Holtmann, M ;
Becker, C ;
Strand, D ;
Czaja, J ;
Schlaak, JF ;
Lehr, HA ;
Autschbach, F ;
Schürmann, G ;
Nishimoto, N ;
Yoshizaki, K ;
Ito, H ;
Kishimoto, T ;
Galle, PR ;
Rose-John, S ;
Neurath, MF .
NATURE MEDICINE, 2000, 6 (05) :583-588
[10]   Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease [J].
Baert, Filip ;
Moortgat, Liesbeth ;
Van Assche, Gert ;
Caenepeel, Philip ;
Vergauwe, Philippe ;
De Vos, Martine ;
Stokkers, Pieter ;
Hommes, Daniel ;
Rutgeerts, Paul ;
Vermeire, Severine ;
D'Haens, Geert .
GASTROENTEROLOGY, 2010, 138 (02) :463-468