Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer

被引：15

作者：

Kutasovic, Jamie R. ^{[1
,2
]}

Reed, Amy E. McCart ^{[1
,2
]}

Sokolova, Anna ^{[1
,3
]}

Lakhani, Sunil R. ^{[1
,3
]}

Simpson, Peter T. ^{[1
]}

机构：

[1] Univ Queensland, Fac Med, UQ Ctr Clin Res, Brisbane, Qld 4029, Australia

[2] QIMR Berghofer Med Res Inst, Herston, Qld 4006, Australia

[3] Royal Brisbane & Womens Hosp, Pathol Queensland, Brisbane, Qld 4029, Australia

来源：

CANCERS | 2020年 / 12卷 / 04期

基金：

英国医学研究理事会;

关键词：

breast cancer; genomics; intra-tumour heterogeneity; metastasis; subclonal diversity; treatment resistance; CIRCULATING TUMOR-CELLS; FACTOR RECEPTOR 2; ADENOID CYSTIC CARCINOMA; NORMAL TISSUE ADJACENT; ESTROGEN-RECEPTOR; MUTATIONAL PROCESSES; SOMATIC MUTATIONS; PROGESTERONE-RECEPTOR; FIELD CANCERIZATION; MOLECULAR PORTRAITS;

D O I：

10.3390/cancers12040848

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is a remarkably complex and diverse disease. Subtyping based on morphology, genomics, biomarkers and/or clinical parameters seeks to stratify optimal approaches for management, but it is clear that every breast cancer is fundamentally unique. Intra-tumour heterogeneity adds further complexity and impacts a patient's response to neoadjuvant or adjuvant therapy. Here, we review some established and more recent evidence related to the complex nature of breast cancer evolution. We describe morphologic and genomic diversity as it arises spontaneously during the early stages of tumour evolution, and also in the context of treatment where the changing subclonal architecture of a tumour is driven by the inherent adaptability of tumour cells to evolve and resist the selective pressures of therapy.

引用

页数：21

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