Mechanobiology of limb musculoskeletal development

被引：25

作者：

Arvind, Varun ^{[1
]}

Huang, Alice H. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Orthopaed, 1 Gustave Levy Pl,Box 1188, New York, NY 10029 USA

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2017年 / 1409卷 / 01期

基金：

美国国家卫生研究院;

关键词：

musculoskeletal; tendon; mechanics; development; mouse; MESENCHYMAL STEM-CELLS; PRIMARY CILIUM; EXTRACELLULAR-MATRIX; SKELETAL-MUSCLE; IN-VITRO; ARTICULAR-CARTILAGE; PROGENITOR CELLS; N-CADHERIN; INTRAFLAGELLAR TRANSPORT; SIGNALING CENTER;

D O I：

10.1111/nyas.13427

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

While there has been considerable progress in identifying molecular regulators of musculoskeletal development, the role of physical forces in regulating induction, differentiation, and patterning events is less well understood. Here, we highlight recent findings in this area, focusing primarily on model systems that test the mechanical regulation of skeletal and tendon development in the limb. We also discuss a few of the key signaling pathways and mechanisms that have been implicated in mechanotransduction and highlight current gaps in knowledge and opportunities for further research in the field.

引用

页码：18 / 32

页数：15

共 141 条

[1]

Arcangelis A.D., 1999, DEVELOPMENT, V126, P3957

[2] The ciliopathies: An emerging class of human genetic disorders [J].

Badano, Jose L. ;

Mitsuma, Norimasa ;

Beales, Phil L. ;

Katsanis, Nicholas .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2006, 7 :125-148

[3] NEUROMUSCULAR BLOCKING PROPERTIES OF A NEW STEROID COMPOUND PANCURONIUM BROMIDE - A PILOT STUDY IN MAN [J].

BAIRD, WLM ;

REID, AM .

BRITISH JOURNAL OF ANAESTHESIA, 1967, 39 (10) :775-&

[4] The Primary Cilium as a Complex Signaling Center [J].

Berbari, Nicolas F. ;

O'Connor, Amber K. ;

Haycraft, Courtney J. ;

Yoder, Bradley K. .

CURRENT BIOLOGY, 2009, 19 (13) :R526-R535

[5] Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis [J].

Bian, Liming ;

Guvendiren, Murat ;

Mauck, Robert L. ;

Burdick, Jason A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (25) :10117-10122

[6] Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors [J].

Blitz, Einat ;

Sharir, Amnon ;

Akiyama, Haruhiko ;

Zelzer, Elazar .

DEVELOPMENT, 2013, 140 (13) :2680-2690

[7] Bone Ridge Patterning during Musculoskeletal Assembly Is Mediated through SCX Regulation of Bmp4 at the Tendon-Skeleton Junction [J].

Blitz, Einat ;

Viukov, Sergey ;

Sharir, Amnon ;

Shwartz, Yulia ;

Galloway, Jenna L. ;

Pryce, Brian A. ;

Johnson, Randy L. ;

Tabin, Clifford J. ;

Schweitzer, Ronen ;

Zelzer, Elazar .

DEVELOPMENTAL CELL, 2009, 17 (06) :861-873

[8]

BOBER E, 1994, DEVELOPMENT, V120, P603

[9] Six1 is not involved in limb tendon development, but is expressed in limb connective tissue under Shh regulation [J].

Bonnin, MA ;

Laclef, C ;

Blaise, R ;

Eloy-Trinquet, S ;

Relaix, F ;

Maire, P ;

Duprez, D .

MECHANISMS OF DEVELOPMENT, 2005, 122 (04) :573-585

[10] The small GTPases rho and rac are required for the establishment of cadherin-dependent cell-cell contacts [J].

Braga, VMM ;

Machesky, LM ;

Hall, A ;

Hotchin, NA .

JOURNAL OF CELL BIOLOGY, 1997, 137 (06) :1421-1431

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