Palladium/Norbornene Chemistry in the Synthesis of Polycyclic Indolines with Simple Nitrogen Sources

被引：8

作者：

Ghasemi, Mehran ^{[1
,2
]}

Jafarpour, Farnaz ^{[1
]}

Habibi, Azizollah ^{[2
]}

机构：

[1] Univ Tehran, Coll Sci, Sch Chem, Tehran 141556455, Iran

[2] Kharazmi Univ, Fac Chem, 43 Mofateh St,Fnghelab Ave, Tehran 1571914911, Iran

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 14期

关键词：

amines; N-alkylindolines; norbornene; palladacycle; urea; CATALYZED INTRAMOLECULAR AMINATION; AROMATIC FUNCTIONALIZATION; PALLADIUM; C(SP(2))-H; CYCLIZATION; DERIVATIVES; NORBORNENE; ALKALOIDS; ROUTE; BONDS;

D O I：

10.1055/s-0039-1707988

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient procedure has been developed to synthesize -indoline derivatives through a palladium-catalyzed Heck reaction/C-H activation/dual amination cascade in one pot. This constitutes the first intermolecular catalytic approach to directly accessN-alkylindolines with a broad substrate scope in the absence of any ligands. This method highlights the use of readily available amines and ureas as the required nitrogen sources in building up the indoline core.

引用

页码：2092 / 2098

页数：7

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