The protective effects of PMC against chronic carbon tetrachloride-induced hepatotoxicity in vivo

被引：25
作者：
Hsiao, G
Lin, YH
Lin, CH
Chou, DS
Lin, WC
Sheu, JR
机构：
[1] Taipei Med Univ, Grad Inst Med Sci, Taipei 110, Taiwan
[2] Taipei Med Univ, Dept Pharmacol, Taipei 110, Taiwan
[3] Taipei Med Univ, Dept Pathol, Taipei 110, Taiwan
[4] Taipei Med Univ, Grad Inst Biomed Technol, Taipei 110, Taiwan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2001年 / 24卷 / 11期
关键词：
2,2,5,7,8-pentamethyl-6-hydroxychromane; antioxidant; carbon tetrachloride; hepatotoxicity;
D O I：
10.1248/bpb.24.1271
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of alpha -tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCl4) intoxication in mice. Moreover, PMC significantly improved the CCl4-induced increase of hepatic glutathione peroxidase, reductase, and superoxide dismutase activities. PMC also restored the decrement in the glutathione content of hepatic tissues in CCl4-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during carbon tetrachloride treatment. Histopathological changes of hepatic lesions induced by carbon tetrachloride were significantly improved by treatment with PMC in a dose-dependent manner. These results suggest that PMC exerts effective protection in chronic chemical-induced hepatic injury in vivo.
引用
收藏
页码：1271 / 1276
页数：6
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