High Dose of Darunavir in Treatment-Experienced HIV-Infected Adolescent Results in Virologic Suppression and Improved CD4 Cell Count

被引：6

作者：

Rakhmanina, Natella Y. ^{[1
]}

Neely, Michael N. ^{[2
]}

Capparelli, Edmund V. ^{[3
,4
]}

机构：

[1] George Washington Univ, Childrens Natl Med Ctr, Sch Med & Hlth Sci, Div Infect Dis,Dept Pediat, Washington, DC 20010 USA

[2] Univ So Calif, Div Pediat Infect Dis, Lab Appl Pharmacokinet, Los Angeles, CA USA

[3] Univ Calif San Diego, Sch Med, Dept Pediat, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Clin Pharm, Skaggs Sch Pharm, La Jolla, CA 92093 USA

来源：

THERAPEUTIC DRUG MONITORING | 2012年 / 34卷 / 03期

基金：

美国国家卫生研究院;

关键词：

darunavir; adolescent; pharmacokinetics; safety; HIV; DARUNAVIR/RITONAVIR; PHARMACOKINETICS; OPTIMIZATION; CHILDREN;

D O I：

10.1097/FTD.0b013e3182511efe

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We describe an unintentional significant overdose of darunavir in a treatment-experienced adolescent with decreased darunavir susceptibility and prior treatment failure on darunavir therapy. Minimal toxicity and improved virologic suppression observed with an overdose have prompted consideration of the continued use of a higher than recommended dose. Pharmacokinetic and pharmacodynamic evaluations justified the individualized use of high-dose darunavir, which resulted in virologic suppression, improved CD4 cell count, and resolution of toxicity.

引用

页码：237 / 241

页数：5

共 15 条

[1]

[Anonymous], 2008, 9 INT WORKSH CLIN PH

[2]

[Anonymous], PREZISTA

[3]

[Anonymous], 9 INT WORKSH CLIN PH

[4]

[Anonymous], 2011, GUIDELINES USE ANTIR, P1

[5] Pharmacokinetics, safety and efficacy of darunavir/ritonavir in treatment-experienced children and adolescents [J].

Blanche, Stephane ;

Bologna, Rosa ;

Cahn, Pedro ;

Rugina, Sorin ;

Flynn, Patricia ;

Fortuny, Claudia ;

Vis, Peter ;

Sekar, Vanitha ;

van Baelen, Ben ;

Dierynck, Inge ;

Spinosa-Guzman, Sabrina .

AIDS, 2009, 23 (15) :2005-2013

[6] DEVELOPMENTAL PHARMACOLOGY IN ADOLESCENCE - THE INAUGURATION OF A NEW FIELD [J].

HEIN, K .

JOURNAL OF ADOLESCENT HEALTH, 1987, 8 (01) :1-2

[7] THE EFFECT OF AGE, GENDER, AND SEXUAL-MATURATION ON THE CAFFEINE BREATH TEST [J].

LAMBERT, GH ;

SCHOELLER, DA ;

KOTAKE, AN ;

FLORES, C ;

HAY, D .

DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS, 1986, 9 (06) :375-388

[8] PUBERTAL CHANGES IN NET RENAL TUBULAR SECRETION OF DIGOXIN [J].

LINDAY, LA ;

DRAYER, DE ;

KHAN, MAA ;

CICALESE, C ;

REIDENBERG, MM .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1984, 35 (04) :438-446

[9] Practical therapeutic drug management in HIV-infected patients: Use of population pharmacokinetic models supplemented by individualized Bayesian dose optimization [J].

Neely, Michael ;

Jelliffe, Roger .

JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 48 (09) :1081-1091

[10]

Neely Michael, 2009, Ther Clin Risk Manag, V5, P595

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