Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

被引：2

作者：

Lo, Wen ^{[2
]}

Ghazaryan, Ara ^{[3
]}

Tso, Chien-Hsin ^{[3
]}

Hu, Po-Sheng ^{[3
]}

Chen, Wei-Liang ^{[3
]}

Kuo, Tsung-Rong ^{[1
]}

Lin, Sung-Jan ^{[4
,5
]}

Chen, Shean-Jen ^{[2
]}

Chen, Chia-Chun ^{[1
]}

Dong, Chen-Yuan ^{[3
,6
,7
]}

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, Taipei 106, Taiwan

[2] Natl Cheng Kung Univ, Dept Engn Sci, Tainan 70101, Taiwan

[3] Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan

[4] Natl Taiwan Univ, Dept Biomed Engn, Taipei 100, Taiwan

[5] Natl Taiwan Univ Hosp 100, Dept Dermatol, Taipei, Taiwan

[6] Natl Taiwan Univ, Ctr Quantum Sci & Engn, Taipei 106, Taiwan

[7] Natl Taiwan Univ, Res Ctr Med Excellence, Div Genom Med, Taipei 100, Taiwan

来源：

APPLIED PHYSICS LETTERS | 2012年 / 100卷 / 21期

关键词：

MULTIPHOTON MICROSCOPY; SKIN; PENETRATION; PATCH;

D O I：

10.1063/1.3701135

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3701135]

引用

页数：4

共 20 条

[1]

Banga A. K., 2010, J PHARM SCI, V99, P1931

[2]

Blankschtein D., 2011, J CONTROL RELEASE, V152, P330

[3]

Blankschtein D., 2001, J INVEST DERMATOL, V117, P16

[4]

Dong C. Y., 2009, BIOMATERIALS, V30, P3002

[5] Multiphoton microscopy in life sciences [J].

König, K .

JOURNAL OF MICROSCOPY, 2000, 200 (02) :83-104

[6]

Kuo TR, 2011, ABSTR PAP AM CHEM S, V241

[7] Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles [J].

Kuo, Tsung-Rong ;

Wu, Chung-Long ;

Hsu, Chih-Ting ;

Lo, Wen ;

Chiang, Shu-Jen ;

Lin, Sung-Jan ;

Dong, Chen-Yuan ;

Chen, Chia-Chun .

BIOMATERIALS, 2009, 30 (16) :3002-3008

[8] Dual-channel two-photon microscopy study of transdermal transport in skin treated with low-frequency ultrasound and a chemical enhancer [J].

Kushner, Joseph ;

Kim, Daekeun ;

So, Peter T. C. ;

Blankschtein, Daniel ;

Langer, Robert S. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (12) :2832-2846

[9] Optical biopsy of liver fibrosis by use of multiphoton microscopy [J].

Lee, HS ;

Liu, Y ;

Chen, HC ;

Chiou, LL ;

Huang, GT ;

Lo, W ;

Dong, CY .

OPTICS LETTERS, 2004, 29 (22) :2614-2616

[10]

MORIEARTY PL, 1993, METHOD FIND EXP CLIN, V15, P407

← 1 2 →