Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: A preliminary report

被引：37

作者：

Wrzosek, Malgorzata ^{[3
]}

Lukaszkiewicz, Jacek ^{[3
]}

Wrzosek, Michal ^{[4
]}

Serafin, Piotr ^{[1
]}

Jakubczyk, Andrzej ^{[1
]}

Klimkiewicz, Anna ^{[1
]}

Matsumoto, Halina ^{[1
]}

Brower, Kirk J. ^{[2
]}

Wojnar, Marcin ^{[1
,2
]}

机构：

[1] Med Univ Warsaw, Dept Psychiat, PL-00665 Warsaw, Poland

[2] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[3] Med Univ Warsaw, Dept Biochem & Clin Chem, PL-00665 Warsaw, Poland

[4] Med Univ Warsaw, Dept Internal Med & Diabetol, PL-00665 Warsaw, Poland

来源：

PSYCHIATRY RESEARCH | 2011年 / 190卷 / 01期

关键词：

Alcoholism; Suicide; HTR2A; MAJOR DEPRESSIVE DISORDER; 1A RECEPTOR GENE; HAPLOTYPE ANALYSIS; ISOFORM TPH2; BEHAVIOR; SEROTONIN; SCHIZOPHRENIA; METAANALYSIS; ABUSE; SNP;

D O I：

10.1016/j.psychres.2011.04.027

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We investigated a relationship between selected polymorphisms: rs6313 in HTR2A, rs6295 in HTR1A and rs1386494 in 7PH2, and suicidal behaviour in 150 alcohol-dependent patients. There was a significant association between more frequent C102C genotype in HTR2A and suicide attempts in alcoholic females. No differences in genotype distribution in HTR1A and TPH2 SNPs were found between patients with and without suicide attempts. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：149 / 151

页数：3

共 29 条

[1]

[Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787

[2] TPH2 polymorphisms may modify clinical picture in treatment-resistant depression [J].

Anttila, Sami ;

Viikki, Merja ;

Huuhka, Kaija ;

Huuhka, Martti ;

Huhtala, Heini ;

Rontu, Riikka ;

Lehtimaki, Terho ;

Leinonen, Esa .

NEUROSCIENCE LETTERS, 2009, 464 (01) :43-46

[3] The 5-HT2A receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients [J].

Arias, B ;

Gastó, C ;

Catalán, R ;

Gutiérrez, B ;

Pintor, L ;

Fañanás, L .

AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 105 (08) :801-804

[4] Decrease in circulating tryptophan availability to the brain after acute ethanol consumption by normal volunteers: Implications for alcohol-induced aggressive behaviour and depression [J].

Badawy, AAB ;

Morgan, CJ ;

Lovett, JWT ;

Bradley, DM ;

Thomas, R .

PHARMACOPSYCHIATRY, 1995, 28 :93-97

[5] Acute alcohol use and suicidal behavior: A review of the literature [J].

Cherpitel, CJ ;

Borges, GLG ;

Wilcox, HC .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2004, 28 (05) :18S-28S

[6] Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality [J].

De Luca, V ;

Voineskos, D ;

Wong, GWH ;

Shinkai, T ;

Rothe, C ;

Strauss, J ;

Kennedy, JL .

PSYCHIATRY RESEARCH, 2005, 134 (02) :195-198

[7] Candidate genes for alcohol dependence: A review of genetic evidence from human studies [J].

Dick, DM ;

Foroud, T .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2003, 27 (05) :868-879

[8]

Du L, 2001, Crisis, V22, P54, DOI 10.1027//0227-5910.22.2.54

[9]

Du LS, 2000, AM J MED GENET, V96, P56, DOI 10.1002/(SICI)1096-8628(20000207)96:1<56::AID-AJMG12>3.0.CO

[10]

2-L

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