Design and synthesis of oxacycles from norbornene derivatives via ring-opening metathesis and ring-rearrangement metathesis

被引：10

作者：

Kotha, Sambasivarao ^{[1
]}

Ravikumar, Ongolu ^{[1
]}

Sreevani, Gaddamedi ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Powai, India

来源：

TETRAHEDRON | 2016年 / 72卷 / 42期

关键词：

Ring-rearrangement metathesis; Spirocycles; Oxacycles; Norbornene derivatives; DIELS-ALDER REACTION; DIVERSITY-ORIENTED APPROACH; ENYNE METATHESIS; RUTHENIUM; OXA; HETEROCYCLES; MECHANISM; LACTAM; BOWLS;

D O I：

10.1016/j.tet.2016.08.073

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Norbornene derivatives containing oxygen atom(s) are found to undergo ring-rearrangement metathesis sequence to deliver cyclic ethers. Here, we have established a simple, efficient and an atom-economic process for the synthesis of fused and spiro-oxacyclic compounds starting with cyclopentadiene. Compounds prepared in this study are difficult to assemble by conventional retrosynthetic routes. (C) 2016 Published by Elsevier Ltd.

引用

页码：6611 / 6615

页数：5

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