High Prediagnosis Inflammation-Related Risk Score Associated with Decreased Ovarian Cancer Survival

被引：4

作者：

Brieger, Katharine K. ^{[1
]}

Phung, Minh Tung ^{[1
]}

Mukherjee, Bhramar ^{[2
]}

Bakulski, Kelly M. ^{[1
]}

Anton-Culver, Hoda ^{[3
]}

Bandera, Elisa, V ^{[4
]}

Bowtell, David D. L. ^{[5
,6
]}

Cramer, Daniel W. ^{[7
,8
,9
]}

DeFazio, Anna ^{[10
,11
,12
]}

Doherty, Jennifer A. ^{[13
]}

Fereday, Sian ^{[5
,6
]}

Fortner, Renee Turzanski ^{[14
]}

Gentry-Maharaj, Aleksandra ^{[15
]}

Goode, Ellen L. ^{[16
]}

Goodman, Marc T. ^{[17
,18
]}

Harris, Holly R. ^{[19
,20
]}

Matsuo, Keitaro ^{[21
,22
]}

Menon, Usha ^{[15
]}

Modugno, Francesmary ^{[23
,24
,25
,26
]}

Moysich, Kirsten B. ^{[27
]}

Qin, Bo ^{[4
]}

Ramus, Susan J. ^{[28
,29
]}

Risch, Harvey A. ^{[30
]}

Rossing, Mary Anne ^{[19
,20
]}

Schildkraut, Joellen M. ^{[31
]}

Trabert, Britton ^{[32
]}

Vierkant, Robert A. ^{[33
]}

Winham, Stacey J. ^{[34
]}

Wentzensen, Nicolas ^{[32
]}

Wu, Anna H. ^{[35
]}

Ziogas, Argyrios ^{[3
]}

Khoja, Lilah ^{[1
]}

Cho, Kathleen R. ^{[36
]}

McLean, Karen ^{[37
]}

Richardson, Jean ^{[35
]}

Grout, Bronwyn

Chase, Anne

Deurloo, Cindy McKinnon

Odunsi, Kunle ^{[38
]}

Nelson, Brad H. ^{[39
]}

Brenton, James D. ^{[40
]}

Terry, Kathryn L. ^{[7
,8
,9
]}

Pharoah, Paul D. P. ^{[41
,42
]}

Berchuck, Andrew ^{[43
]}

Hanley, Gillian E. ^{[44
]}

Webb, Penelope M. ^{[45
]}

Pike, Malcolm C. ^{[35
,46
]}

Pearce, Celeste Leigh ^{[1
]}

机构：

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 1415 Washington Hts, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA

[3] Univ Calif Irvine, Sch Med, Dept Med, Irvine, CA 92717 USA

[4] Rutgers Canc Inst New Jersey, Canc Epidemiol & Hlth Outcomes, New Brunswick, NJ USA

[5] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[6] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia

[7] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[8] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, 75 Francis St, Boston, MA 02115 USA

[9] Harvard Med Sch, Boston, MA 02115 USA

[10] Westmead Inst Med Res, Ctr Canc Res, Westmead, NSW, Australia

[11] Univ Sydney, Westmead, NSW, Australia

[12] Westmead Hosp, Dept Gynaecol Oncol, Westmead, NSW, Australia

[13] Univ Utah, Sch Med, Huntsman Canc Inst, Dept Populat Hlth Sci, Salt Lake City, UT USA

[14] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[15] UCL, MRC Clin Trials Unit, Inst Clin Trials & Methodol, London, England

[16] Mayo Clin, Div Epidemiol, Dept Quantitat Hlth Sci, Rochester, MN USA

[17] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Genet Program, Los Angeles, CA 90048 USA

[18] Cedars Sinai Med Ctr, Community & Populat Hlth Res Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA

[19] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA

[20] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA

[21] Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi, Japan

[22] Nagoya Univ, Dept Canc Epidemiol, Grad Sch Med, Nagoya, Aichi, Japan

[23] Magee Womens Res Inst, Womens Canc Res Ctr, Pittsburgh, PA USA

[24] UPMC Hillman Canc Ctr, Pittsburgh, PA USA

[25] Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, Pittsburgh, PA USA

[26] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA

[27] Roswell Park Comprehens Canc Ctr, Div Canc Prevent & Control, Buffalo, NY USA

[28] Univ NSW Sydney, Fac Med, Sch Womens & Childrens Hlth, Sydney, NSW, Australia

[29] Univ NSW Sydney, Lowy Canc Res Ctr, Adult Canc Program, Sydney, NSW, Australia

[30] Yale Sch Publ Hlth, Chron Dis Epidemiol Dept, New Haven, CT USA

[31] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[32] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[33] Mayo Clin, Div Clin Trials & Biostat, Dept Quantitat Hlth Sci, Rochester, MN USA

[34] Mayo Clin, Div Computat Biol, Dept Quantitat Hlth Sci, Rochester, MN USA

[35] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA

[36] Univ Michigan, Dept Pathol, Michigan Med, Ann Arbor, MI USA

[37] Univ Michigan, Dept Obstet & Gynecol, Div Gynecol Oncol, Michigan Med, Ann Arbor, MI 48109 USA

[38] Univ Chicago Med, Comprehens Canc Ctr, Chicago, IL USA

[39] British Columbia Canc Agcy, Deeley Res Ctr, Victoria, BC, Canada

[40] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England

[41] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England

[42] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

[43] Duke Univ, Sch Med, Div Gynecol Oncol, Durham, NC USA

[44] Univ British Columbia, Dept Obstet & Gynecol, Fac Med, Vancouver, BC, Canada

[45] QIMR Berghofer Med Res Inst, Dept Populat Hlth, Brisbane, Qld, Australia

[46] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2022年 / 31卷 / 02期

基金：

美国国家卫生研究院; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

HORMONE REPLACEMENT THERAPY; C-REACTIVE PROTEIN; POOLED ANALYSIS; CIGARETTE-SMOKING; T-CELLS; DISEASE; WOMEN; DIAGNOSIS; ESTROGENS; POWDER;

D O I：

10.1158/1055-9965.EPI-21-0977

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: There is suggestive evidence that inflammation is related to ovarian cancer survival. However, more research is needed to identify inflammation-related factors that are associated with ovarian cancer survival and to determine their combined effects. Methods: This analysis used pooled data on 8,147 women with invasive epithelial ovarian cancer from the Ovarian Cancer Association Consortium. The prediagnosis inflammation-related exposures of interest included alcohol use; aspirin use; other nonsteroidal anti-inflammatory drug use; body mass index; environmental tobacco smoke exposure; history of pelvic inflammatory disease, polycystic ovarian syndrome, and endometriosis; menopausal hormone therapy use; physical inactivity; smoking status; and talc use. Using Cox proportional hazards models, the relationship between each exposure and survival was assessed in 50% of the data. A weighted inflammation-related risk score (IRRS) was developed, and its association with survival was assessed using Cox proportional hazards models in the remaining 50% of the data. Results: There was a statistically significant trend of increasing risk of death per quartile of the IRRS [HR - 1.09; 95% confidence interval (CI), 1.03-1.14]. Women in the upper quartile of the IRRS had a 31% higher death rate compared with the lowest quartile (95% CI, 1.11-1.54). Conclusions: A higher prediagnosis IRRS was associated with an increased mortality risk after an ovarian cancer diagnosis. Further investigation is warranted to evaluate whether postdiagnosis exposures are also associated with survival. Impact: Given that pre- and postdiagnosis exposures are often correlated and many are modifiable, our study results can ultimately motivate the development of behavioral recommendations to enhance survival among patients with ovarian cancer.

引用

页码：443 / 452

页数：10

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