Pro-inflammatory Cytokine Expression of Spleen Dendritic Cells in Mouse Toxoplasmosis

被引：7

作者：

Nam, Ho-Woo ^{[2
]}

Ahn, Hye-Jin ^{[2
]}

Yang, Hyun-Jong ^{[1
]}

机构：

[1] Ewha Womans Univ, Sch Med, Dept Parasitol, Seoul 158710, South Korea

[2] Catholic Univ Korea, Dept Parasitol, Coll Med, Seoul 137701, South Korea

来源：

KOREAN JOURNAL OF PARASITOLOGY | 2011年 / 49卷 / 02期

关键词：

Toxoplasma gondii; spleen; dendritic cell; cytokine; FACS; mouse; GONDII INFECTION; LANGERHANS CELLS; IL-12; PRODUCTION; CUTTING EDGE; T-CELLS; INTERLEUKIN-10; RESISTANCE; INDUCTION; SUBTYPES; THYMUS;

D O I：

10.3347/kjp.2011.49.2.109

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Dendritic cells have been known as a member of strong innate immune cells against infectious organelles. In this study, we evaluated the cytokine expression of splenic dendritic cells in chronic mouse toxoplasmosis by tissue cyst-forming Me49 strain and demonstrated the distribution of lymphoid dendritic cells by fluorescence-activated cell sorter (FACS). Pro-inflammatory cytokines, such as IL-1 alpha, IL-1 beta, IL-6, and IL-10 increased rapidly at week 1 post-infection (PI) and peaked at week 3 PI. Serum IL-10 level followed the similar patterns. FACS analysis showed that the number of CD8 alpha(+)/CD11c(+) splenic dendritic cells increased at week 1 and peaked at week 3 PI. In conclusion, mouse splenic dendritic cells showed early and rapid cytokine changes and may have important protective roles in early phases of murine toxoplasmosis.

引用

页码：109 / 114

页数：6

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