A new antitumor compound from the plant Oryctanthus sp as a VEGF receptor binding inhibitor

被引：10

作者：

Hegde, VR ^{[1
]}

Pu, HY ^{[1
]}

Patel, M ^{[1
]}

Jachens, A ^{[1
]}

Gullo, VP ^{[1
]}

Chan, TM ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 22期

关键词：

D O I：

10.1016/j.bmcl.2005.08.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 70% aqueous methanolic extract of the Peruvian plant Oryctanthus sp. was found to contain a novel saccharide of a diene alpha,omega-diacid. Compound I was identified as an inhibitor of the VEGF receptor. The structure of this compound was established based on NMR studies. Compound 1 inhibited ligand binding to the VEGF receptor with an IC50 of 5.0 mu M. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：4907 / 4909

页数：3

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