Interconversion between [2Fe-2S] and [4Fe-4S] cluster glutathione complexes

被引：9

作者：

Invernici, Michele ^{[1
,2
]}

Selvolini, Giulia ^{[3
]}

Silva, Jose Malanho ^{[1
,3
]}

Marrazza, Giovanna ^{[3
]}

Ciofi-Baffoni, Simone ^{[1
,3
]}

Piccioli, Mario ^{[1
,2
,3
]}

机构：

[1] Univ Florence, Magnet Resonance Ctr CERM, Via L Sacconi 6, I-50019 Sesto Fiorentino, Italy

[2] Consorzio Interuniv Risonanze Magnet Metalloprot, Via L Sacconi 6, I-50019 Sesto Fiorentino, Italy

[3] Univ Florence, Dept Chem Ugo Schiff, Via Lastruccia 3, I-50019 Sesto Fiorentino, Italy

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 21期

基金：

欧盟地平线“2020”;

关键词：

IRON-SULFUR; MITOCHONDRIAL ABCB7; METAL-COMPLEXES; MECHANISM; CYTOSOL; CELLS; PH;

D O I：

10.1039/d1cc03566e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present here how different iron-sulfide-glutathione ratios, applied in in vitro conditions comparable to those present in the mitochondrial matrix, affect the speciation of iron-sulfur cluster glutathione complexes. An excess of sulfide with respect to iron ions promotes the formation of a tetranuclear [(Fe2Fe2S4)-Fe-II-S-III(GS)(4)](2-) complex, while an excess of iron ions favors the formation of a dinuclear [(FeFeS2)-Fe-II-S-III(GS)(4)](3-) complex. These two complexes establish an interconversion equilibrium. The latter might play a role in the composition of the mitochondrial labile iron pool potentially contributing to the regulation of cellular iron homeostasis.

引用

页码：3533 / 3536

页数：4

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