Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation

被引：94

作者：

Schuetz, Catharina ^{[1
]}

Hoenig, Manfred ^{[1
]}

Moshous, Despina ^{[2
,3
]}

Weinstock, Christof ^{[4
]}

Castelle, Martin ^{[2
]}

Bendavid, Matthieu ^{[2
]}

Shimano, Kristin ^{[5
]}

Tolbert, Vanessa ^{[5
]}

Schulz, Ansgar S. ^{[1
]}

Dvorak, Christopher C. ^{[5
]}

机构：

[1] Univ Med Ctr Ulm, Dept Pediat & Adolescent Med, Eythstr 24, D-89075 Ulm, Germany

[2] Hop Necker Enfants Malad, AP HP, Unite Immunohematol & Rhumatol Pediat, Paris, France

[3] Univ Paris 05, Imagine Inst, INSERM UMR 1163, Sorbonne Paris Cite, Paris, France

[4] Ulm Univ, Inst Transfus Med, Ulm, Germany

[5] Univ Calif San Francisco, Div Allergy Immunol & Blood & Marrow Transplant, Benioff Childrens Hosp, 550 16th St,4th Floor,Box 0434, San Francisco, CA 94143 USA

来源：

BLOOD ADVANCES | 2018年 / 2卷 / 19期

关键词：

MULTIPLE-MYELOMA; CD38;

D O I：

10.1182/bloodadvances.2018020883

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

New-onset autoimmune hemolytic anemia (AIHA) occurs in 2% to 6% of pediatric patients post-hematopoietic stem cell transplantation (HSCT) and is a significant complication. Incomplete immune recovery following HSCT may predispose to immune dysregulation including autoimmune cytopenias. We describe an innovative therapy for AIHA refractory to proteasome inhibition. In potentially life-threatening AIHA in the context of HSCT, daratumumab may be an effective rescue therapy.

引用

页码：2550 / 2553

页数：4

共 6 条

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