BCG-induced trained immunity: can it offer protection against COVID-19?

被引：366

作者：

O'Neill, Luke A. J. ^{[1
]}

Netea, Mihai G. ^{[1
,2
,3
,4
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Dublin, Ireland

[2] Radboud Univ Nijmegen, Dept Internal Med, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Ctr Infect Dis, Nijmegen, Netherlands

[4] Univ Bonn, Immunol & Metab Life & Med Sci Inst, Bonn, Germany

来源：

NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 06期

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

NONSPECIFIC PROTECTION; VIRAL-INFECTION; VACCINATION; RESISTANCE; VIRUS; MICE;

D O I：

10.1038/s41577-020-0337-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacillus Calmette-Guerin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19. Could the BCG vaccine be used to bridge the gap until a specific COVID-19 vaccine is developed? Luke O'Neill and Mihai Netea discuss the science behind this approach.

引用

页码：335 / 337

页数：3

共 15 条

[1] Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? [J].

Aaby, Peter ;

Roth, Adam ;

Ravn, Henrik ;

Napirna, Bitiguida Mutna ;

Rodrigues, Amabelia ;

Lisse, Ida Maria ;

Stensballe, Lone ;

Diness, Birgitte Rode ;

Lausch, Karen Rokkedal ;

Lund, Najaaraq ;

Biering-Sorensen, Sofie ;

Whittle, Hilton ;

Benn, Christine Stabell .

JOURNAL OF INFECTIOUS DISEASES, 2011, 204 (02) :245-252

[2] BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity [J].

Arts, Rob J. W. ;

Moorlag, Simone J. C. F. M. ;

Novakovic, Boris ;

Li, Yang ;

Wang, Shuang-Yin ;

Oosting, Marije ;

Kumar, Vinod ;

Xavier, Ramnik J. ;

Wijmenga, Cisca ;

Joosten, Leo A. B. ;

Reusken, Chantal B. E. M. ;

Benn, Christine S. ;

Aaby, Peter ;

Koopmans, Marion P. ;

Stunnenberg, Hendrik G. ;

van Crevel, Reinout ;

Netea, Mihai G. .

CELL HOST & MICROBE, 2018, 23 (01) :89-+

[3] Is global BCG vaccination-induced trained immunity relevant to the progression of SARS-CoV-2 pandemic? [J].

Gursel, Mayda ;

Gursel, Ihsan .

ALLERGY, 2020, 75 (07) :1815-1819

[4] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].

Huang, Chaolin ;

Wang, Yeming ;

Li, Xingwang ;

Ren, Lili ;

Zhao, Jianping ;

Hu, Yi ;

Zhang, Li ;

Fan, Guohui ;

Xu, Jiuyang ;

Gu, Xiaoying ;

Cheng, Zhenshun ;

Yu, Ting ;

Xia, Jiaan ;

Wei, Yuan ;

Wu, Wenjuan ;

Xie, Xuelei ;

Yin, Wen ;

Li, Hui ;

Liu, Min ;

Xiao, Yan ;

Gao, Hong ;

Guo, Li ;

Xie, Jungang ;

Wang, Guangfa ;

Jiang, Rongmeng ;

Gao, Zhancheng ;

Jin, Qi ;

Wang, Jianwei ;

Cao, Bin .

LANCET, 2020, 395 (10223) :497-506

[5] ENHANCEMENT OF NON-SPECIFIC RESISTANCE TO VIRAL-INFECTION BY MURAMYLDIPEPTIDE AND ITS ANALOGS [J].

IKEDA, S ;

NEGISHI, T ;

NISHIMURA, C .

ANTIVIRAL RESEARCH, 1985, 5 (04) :207-215

[6] Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes [J].

Kleinnijenhuis, Johanneke ;

Quintin, Jessica ;

Preijers, Frank ;

Joosten, Leo A. B. ;

Ifrim, Daniela C. ;

Saeed, Sadia ;

Jacobs, Cor ;

van Loenhout, Joke ;

de Jong, Dirk ;

Stunnenberg, Hendrik G. ;

Xavier, Ramnik J. ;

van der Meer, Jos W. M. ;

van Crevel, Reinout ;

Netea, Mihai G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (43) :17537-17542

[7] COVID-19: consider cytokine storm syndromes and immunosuppression [J].

Mehta, Puja ;

McAuley, Daniel F. ;

Brown, Michael ;

Sanchez, Emilie ;

Tattersall, Rachel S. ;

Manson, Jessica J. .

LANCET, 2020, 395 (10229) :1033-1034

[8] Non-specific effects of BCG vaccine on viral infections [J].

Moorlag, S. J. C. F. M. ;

Arts, R. J. W. ;

van Crevel, R. ;

Netea, M. G. .

CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (12) :1473-1478

[9]

Nemes E, 2018, NEW ENGL J MED, V379, P138, DOI [10.1056/NEJMoa1714021, 10.1056/nejmoa1714021]

[10] Trained immunity: A program of innate immune memory in health and disease [J].

Netea, Mihai G. ;

Joosten, Leo A. B. ;

Latz, Eicke ;

Mills, Kingston H. G. ;

Natoli, Gioacchino ;

Stunnenberg, Hendrik G. ;

O'Neill, Luke A. J. ;

Xavier, Ramnik J. .

SCIENCE, 2016, 352 (6284) :427

← 1 2 →