Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression

被引：14
作者：
Chen, Zhuang [1 ]
Yuan, Rui [1 ]
Hu, Shengyun [1 ]
Yuan, Weitang [1 ]
Sun, Zhenqiang [1 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Colorectal Surg, Zhengzhou, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
myeloid-derived suppressor cells; exosome; tumor immunity; cancer; immune escape; PRE-METASTATIC NICHE; EXTRACELLULAR VESICLES; MULTIPLE-MYELOMA; STEM-CELLS; PROTEINS; MACROPHAGES; MDSC; DIFFERENTIATION; IDENTIFICATION; PROLIFERATION;
D O I：
10.3389/fimmu.2022.817942
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of immature myeloid cells and exhibit obvious immunomodulatory functions. Exosomes released by MDSCs (MDSCs-Exos) have similar effects to parental MDSCs in regulating tumor immunity. In this review, we provided a comprehensive description of the characteristics, functions and mechanisms of exosomes. We analyzed the immunosuppressive, angiogenesis and metastatic effects of MDSCs-Exos in different tumors through multiple perspectives. Immunotherapy targeting MDSCs-Exos has demonstrated great potential in cancers and non-cancerous diseases.
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收藏
页数：13
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