Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression

被引：19

作者：

Chen, Zhuang ^{[1
]}

Yuan, Rui ^{[1
]}

Hu, Shengyun ^{[1
]}

Yuan, Weitang ^{[1
]}

Sun, Zhenqiang ^{[1
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Colorectal Surg, Zhengzhou, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

myeloid-derived suppressor cells; exosome; tumor immunity; cancer; immune escape; PRE-METASTATIC NICHE; EXTRACELLULAR VESICLES; MULTIPLE-MYELOMA; STEM-CELLS; PROTEINS; MACROPHAGES; MDSC; DIFFERENTIATION; IDENTIFICATION; PROLIFERATION;

D O I：

10.3389/fimmu.2022.817942

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of immature myeloid cells and exhibit obvious immunomodulatory functions. Exosomes released by MDSCs (MDSCs-Exos) have similar effects to parental MDSCs in regulating tumor immunity. In this review, we provided a comprehensive description of the characteristics, functions and mechanisms of exosomes. We analyzed the immunosuppressive, angiogenesis and metastatic effects of MDSCs-Exos in different tumors through multiple perspectives. Immunotherapy targeting MDSCs-Exos has demonstrated great potential in cancers and non-cancerous diseases.

引用

页数：13

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