Kihito prevents corticosterone-induced brain dysfunctions in mice

被引：7

作者：

Araki, Ryota ^{[1
]}

Tachioka, Hayato ^{[1
]}

Kita, Ayami ^{[1
]}

Fujiwara, Hironori ^{[2
,4
]}

Toume, Kazufumi ^{[3
]}

Matsumoto, Kinzo ^{[2
,5
]}

Yabe, Takeshi ^{[1
]}

机构：

[1] Setsunan Univ, Fac Pharmaceut Sci, Lab Funct Biomol & Chem Pharmacol, 45-1 Nagaotoge Cho, Hirakata, Osaka 5730101, Japan

[2] Univ Toyama, Inst Nat Med, Div Med Pharmacol, 2630 Sugitani, Toyama 9300194, Japan

[3] Univ Toyama, Inst Nat Med, Div Pharmacognosy, 2630 Sugitani, Toyama 9300194, Japan

[4] Iryo Sosei Univ, Fac Pharm, 5-5-1 Lino, Iwaki, Fukushima 9708551, Japan

[5] Daiichi Univ Pf Pharm, Ctr Supporting Pharmaceut Educ, Minami Ku, 22-1 Tamagawa Machi, Fukuoka 8158511, Japan

来源：

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE | 2021年 / 11卷 / 06期

关键词：

Corticosterone; Depression; Kihito; Spatial memory; Stress; INDUCED MEMORY IMPAIRMENT; HIPPOCAMPAL NEUROGENESIS; CELL-PROLIFERATION; STRESS RESPONSES; MOUSE MODEL; DEPRESSION; EXTRACT; ADAPTATION; SPINOSIN; SPINES;

D O I：

10.1016/j.jtcme.2021.05.002

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Kihito (KIT; Gui Pi Tang) is a traditional herbal medicine that is used for treatment of neuropsychiatric disorders such as depression, anxiety, neurosis and insomnia in China and Japan. Recently, it has also been shown that KIT improves cognitive dysfunction in patients with Alzheimer's disease. In this study, to investigate the mechanisms underlying the effects of KIT on stress-induced brain dysfunctions such as a depressed state and memory impairment, we examined whether KIT prevents behavioral and neurophysiological abnormalities in mice treated chronically with corticosterone (CORT). CORT (40 mg/ kg/day, s.c.) and KIT (1000 mg/kg/day, p.o.) were given to 7-week-old male ddY mice for 14 days. Twentyfour hours after the last treatment, depression-like behavior in the forced swim test, spatial memory in the Barnes maze test, cell survival and the number of new-born immature neurons, dendritic spine density and expression levels of mRNA for neurotrophic factors were analyzed. Depression-like behavior and spatial memory impairment were observed in CORT-treated mice without KIT treatment. Hippocampal cell survival, the number of hippocampal new-born immature neurons, hippocampal and accumbal dendritic spine density and mRNA levels for neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) were decreased in CORT-treated mice without KIT treatment. KIT prevented CORT-induced depression-like behavior, spatial memory impairment, and decreases in hippocampal cell survival, the number of hippocampal new-born immature neurons, accumbal dendritic spine density and GDNF mRNA. KIT may ameliorate stress-induced brain dysfunctions via prevention of adverse effects of CORT on cell survival, new-born immature neurons, spine density and neurotrophic factors. (c) 2021 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. This is an open access article under the CC BY license (http://creativecommons.org/licenses/ by/4.0/).

引用

页码：513 / 519

页数：7

共 31 条

[1] Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice [J].