Impact of the C-reactive protein to albumin ratio on long-term outcomes after hepatic resection for colorectal liver metastases

被引:40
作者
Haruki, Koichiro [1 ]
Shiba, Hiroaki [1 ]
Horiuchi, Takashi [1 ]
Sakamoto, Taro [1 ]
Gocho, Takeshi [1 ]
Fujiwara, Yuki [1 ]
Furukawa, Kenei [1 ]
Misawa, Takeyuki [1 ]
Yanaga, Katsuhiko [1 ]
机构
[1] Jikei Univ, Dept Surg, Sch Med, Tokyo, Japan
关键词
Colorectal liver metastasis; CRP; Albumin; Inflammation-based prognostic score; PROTEIN/ALBUMIN RATIO; PROGNOSTIC SCORE; PREOPERATIVE NEUTROPHIL; CURATIVE RESECTION; LYMPHOCYTE RATIO; INFLAMMATION; SURVIVAL; CANCER; RECURRENCE; PREDICTOR;
D O I
10.1016/j.amjsurg.2017.02.001
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: The aim of this study is to investigate the association C-reactive protein to albumin (CRP/Alb) ratio, a novel inflammation based prognostic score, and long-term outcomes among patients with colorectal liver metastases (CRLM) after hepatic resection. Methods: We retrospectively investigated 106 patients who underwent hepatic resection for CRLM and explored the relationship between CRP/Alb ratio and long-term outcomes. Results: In multivariate analysis, more than 4 lymph node metastases (p = 0.003), presence of neo-adjuvant chemotherapy (p = 0.008) and CRP/Alb ratio >= 0.04 (p = 0.021) were independent and significant predictors of cancer recurrence, while more than 4 lymph node metastases (p = 0.001), presence of neo-adjuvant chemotherapy (p < 0.001), and CRP/Alb ratio >= 0.04 (p = 0.002) were independent and significant predictors of poor overall survival. Conclusions: The CRP/Alb ratio seems to be a predictor of poor long-term outcomes in patients with CRLM after hepatic resection. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码:752 / 756
页数:5
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