Historical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human blood

被引:268
作者
Olsen, GW
Huang, HY
Helzlsouer, KJ
Hansen, KJ
Butenhoff, JL
Mandel, JH
机构
[1] 3M Co, Dept Med, St Paul, MN 55144 USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[3] Johns Hopkins Univ, George W Comstock Ctr Publ Hlth Res & Prevent, Baltimore, MD USA
[4] St Johns Mercy Med Ctr, Womens Ctr Hlth & Med, Prevent & Res Ctr, Baltimore, MD USA
[5] 3M Co, Environm Lab, St Paul, MN 55144 USA
关键词
fluorochemicals; perfluorohexanesulfonate; perfluorooctanesulfonate; perfluorooctanoate; PFHS; PFOA; PFOS;
D O I
10.1289/ehp.7544
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a large community health study. The study included a total of 356 samples (178 front each time period). These samples were analyzed by high-pressure liquid chromatography/tandem mass spectrometry methods. The median 1974 and 1989 fluorochemical concentrations, respectively, were as follows: PFOS, 29.5 ng/mL vs. 34.7 ng/mL; PFOA, 2.3 ng/mL vs. 5.6 ng/mL; perfluorohexanesulfonate (PFHS), 1.6 ng/mL vs. 2.4 ng/mL; and N-ethyl perfluorooctanesulfonamidoacetate (PFOSAA), less than the lower limit of quantitation (LLOQ; 1.6 ng/mL, vs. 3.4 ng/mL. For N-methyl perfluorooctanesulfonamidoacetate, respectively). Statistical analysis of 58 paired samples indicated that serum concentrations of PFOS, PFOSAA, PFOA, PFHS, and M570 were significantly (p < 0.001) higher in 1989 than in 1974. The data front 1989 were then compared with geometric mean fluorochemical concentrations of serum samples collected in 2001 from 108 American Red Cross adult blood donors from the same region. Except for M570, there were no statistically significant (p < 0.05) geometric mean fluorochemical concentration differences between the 1989 and 2001 samples. In conclusion, based on this study, population, PFOS and other serum fluorochemical concentrations have increased between 1974 and 1989. Comparison with other regional data collected in 2001 did not suggest a continued increase in concentrations since 1989.
引用
收藏
页码:539 / 545
页数:7
相关论文
共 56 条
  • [11] SERUM LEVELS OF RETINOL, BETA-CAROTENE, AND ALPHA-TOCOPHEROL IN OLDER ADULTS
    COMSTOCK, GW
    MENKES, MS
    SCHOBER, SE
    VUILLEUMIER, JP
    HELSING, KJ
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1988, 127 (01) : 114 - 123
  • [12] Global distribution of perfluorooctane sulfonate in wildlife
    Giesy, JP
    Kannan, K
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2001, 35 (07) : 1339 - 1342
  • [13] GLESY JP, 2001, ENVIRON SCI TECHNOL, V35, P3065
  • [14] GUY WS, 1972, THESIS U ROCHESTER S
  • [15] CHARACTERIZATION OF FLUORINATED METABOLITES BY A GAS CHROMATOGRAPHIC-HELIUM MICROWAVE PLASMA DETECTOR - THE BIOTRANSFORMATION OF 1H,1H,2H,2H-PERFLUORODECANOL TO PERFLUOROOCTANOATE
    HAGEN, DF
    BELISLE, J
    JOHNSON, JD
    VENKATESWARLU, P
    [J]. ANALYTICAL BIOCHEMISTRY, 1981, 118 (02) : 336 - 343
  • [16] Compound-specific, quantitative characterization of organic: Fluorochemicals in biological matrices
    Hansen, KJ
    Clemen, LA
    Ellefson, ME
    Johnson, HO
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2001, 35 (04) : 766 - 770
  • [17] Quantitative characterization of trace levels of PFOS and PFOA in the Tennessee River
    Hansen, KJ
    Johnson, HO
    Eldridge, JS
    Butenhoff, JL
    Dick, LA
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2002, 36 (08) : 1681 - 1685
  • [18] THE MECHANISM UNDERLYING THE HYPOLIPEMIC EFFECT OF PERFLUOROOCTANOIC ACID (PFOA), PERFLUOROOCTANE SULFONIC-ACID (PFOSA) AND CLOFIBRIC ACID
    HAUGHOM, B
    SPYDEVOLD, O
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1128 (01) : 65 - 72
  • [19] Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and sprague-dawley rats in vivo
    Hu, WY
    Jones, PD
    Upham, BL
    Trosko, JE
    Lau, C
    Giesy, JP
    [J]. TOXICOLOGICAL SCIENCES, 2002, 68 (02) : 429 - 436
  • [20] Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: Assessment of PFOS exposure in a susceptible population during pregnancy
    Inoue, K
    Okada, F
    Ito, R
    Kato, S
    Sasaki, S
    Nakajima, S
    Uno, A
    Saijo, Y
    Sata, F
    Yoshimura, Y
    Kishi, R
    Nakazawa, H
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2004, 112 (11) : 1204 - 1207