An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis

被引：16

作者：

Jimenez, Antonio M. Jimenez ^{[1
]}

De Lima, Marcos ^{[2
]}

Komanduri, Krishna, V ^{[1
]}

Wang, Trent P. ^{[1
]}

Zhang, Mei-Jie ^{[3
,4
]}

Chen, Karen ^{[3
]}

Abdel-Azim, Hisham ^{[5
]}

Abid, Muhammad Bilal ^{[6
,7
]}

Aljurf, Mahmoud ^{[8
]}

Alkhateeb, Hassan ^{[9
]}

Assal, Amer ^{[10
]}

Bacher, Ulrike ^{[11
]}

Baron, Frederic ^{[12
,13
]}

Battiwalla, Minoo ^{[14
]}

Beitinjaneh, Amer ^{[1
]}

Bejanyan, Nelli ^{[15
]}

Bhatt, Vijaya Raj ^{[16
]}

Byrne, Michael ^{[17
]}

Cahn, Jean-Yves ^{[18
]}

Cairo, Mitchell ^{[19
]}

Castillo, Paul ^{[20
]}

Copelan, Edward ^{[21
]}

DeFilipp, Zachariah ^{[22
]}

Diaz Perez, Miguel Angel ^{[23
]}

Elsawy, Mahmoud ^{[24
]}

Gale, Robert Peter ^{[25
]}

George, Biju ^{[26
]}

Grunwald, Michael R. ^{[21
]}

Hildebrandt, Gerhard C. ^{[27
]}

Hogan, William J. ^{[28
]}

Kanakry, Christopher G. ^{[29
]}

Kansagra, Ankit ^{[30
]}

Kharfan-Dabaja, Mohamed A. ^{[31
]}

Khera, Nandita ^{[32
]}

Krem, Maxwell M. ^{[33
]}

Lazaryan, Aleksandr ^{[15
]}

Maakaron, Joseph ^{[34
]}

Martino, Rodrigo ^{[35
]}

McGuirk, Joseph ^{[36
]}

Michelis, Fotios, V ^{[37
]}

Milone, Giuseppe ^{[38
]}

Mishra, Asmita ^{[15
]}

Murthy, Hemant S. ^{[31
]}

Mussetti, Alberto ^{[39
,40
]}

Nathan, Sunita ^{[41
]}

Nishihori, Taiga ^{[15
]}

Olsson, Richard F. ^{[42
,43
]}

Palmisiano, Neil ^{[44
]}

Patel, Sagar ^{[45
]}

Saad, Ayman ^{[46
]}

机构：

[1] Univ Miami, Miller Sch Med, Div Transplantat & Cellular Therapy, Miami, FL 33136 USA

[2] Univ Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA

[3] Med Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA

[5] Univ Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90007 USA

[6] Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA

[7] Med Coll Wisconsin, Dept Med, Div Infect Dis, Milwaukee, WI 53226 USA

[8] King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia

[9] Mayo Clin Rochester, Rochester, MN USA

[10] Columbia Univ, Dept Med, Irving Med Ctr, Bone Marrow Transplant & Cell Therapy Program, New York, NY USA

[11] Univ Bern, Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland

[12] CHU, Liege, Belgium

[13] Univ Liege, Liege, Belgium

[14] Sarah Cannon Blood Canc Network, Nashville, TN USA

[15] H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA

[16] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA

[17] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[18] Univ Grenoble Alpes, Dept Hematol, CHU Grenoble Alpes, Grenoble, France

[19] New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA

[20] UF Hlth Shands Childrens Hosp, Gainesville, FL USA

[21] Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA

[22] Massachusetts Gen Hosp, Lematopoiet Cell Transplant & Cellular Therapy Pr, Boston, MA 02114 USA

[23] Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain

[24] Dalhousie Univ, Dept Med, Div Hematol, Halifax, NS, Canada

[25] Imperial Coll London, Haematol Res Ctr, Dept Immunol & Inflammat, London, England

[26] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India

[27] Univ Kentucky, Markey Canc Ctr, Lexington, KY USA

[28] Mayo Clin, Div Hematol BMT, Rochester, MN USA

[29] NCI, Expt Transplantat & Immunotherapy Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[30] UT Southwestern Med Ctr, Blood & Marrow Transplant Program, Dallas, TX USA

[31] Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA

[32] Mayo Clin, Dept Hematol Oncol, Phoenix, AZ USA

[33] Univ Kentucky, Coll Med, Markey Canc Ctr, Lexington, KY USA

[34] Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA

[35] Hosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain

[36] Univ Kansas Canc Ctr, Div Hematol Malignancies & Cellular Therapeut, Minneapolis, MN USA

[37] Princess Margaret Canc Ctr, Allogene Blood & Marrow Transplant Program, Toronto, ON, Canada

[38] Azienda Osped Univ Policlin San Marco, Catania, Italy

[39] Inst Catala Oncol Hosp, Hematol Dept, Barcelona, Spain

[40] IDIBELL Inst Catala Oncol, Lhospitalet De Llobregat, El Prat De Llob, Spain

[41] Rush Univ, Med Ctr, Sect Bone Marrow Transplant & Cell Therapy, Chicago, IL USA

[42] Karolinska Inst, Dept Lab Med, Stockholm, Sweden

[43] Uppsala Univ, Ctr Clin Res Sormland, Uppsala, Sweden

[44] Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[45] Univ Utah, Huntsman Canc Inst, Blood & Marrow Transplant Program, Salt Lake City, UT USA

[46] Ohio State Univ, Div Hematol, Columbus, OH 43210 USA

[47] Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan

[48] St Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA

[49] Northside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA

[50] Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands

来源：

BONE MARROW TRANSPLANTATION | 2021年 / 56卷 / 12期

关键词：

ACUTE MYELOGENOUS LEUKEMIA; ADULT PATIENTS; MONOSOMAL KARYOTYPE; PROGNOSTIC IMPACT; CLASSIFICATION; RECOMMENDATIONS; AML; MANAGEMENT; DIAGNOSIS; OUTCOMES;

D O I：

10.1038/s41409-021-01450-3

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Cytogenetic and molecular abnormalities are known to influence post-transplant outcomes in acute myeloid leukemia (AML) but data assessing the prognostic value of combined genetic models in the HCT setting are limited. We developed an adapted European LeukemiaNet (aELN) risk classification based on available genetic data reported to the Center for International Blood and Marrow Transplant Research, to predict post-transplant outcomes in 2289 adult AML patients transplanted in first remission, between 2013 and 2017. Patients were stratified according to aELN into three groups: favorable (Fav, N = 181), intermediate (IM, N = 1185), and adverse (Adv, N = 923). Univariate analysis demonstrated significant differences in 2-year overall survival (OS) (Fav: 67.7%, IM: 64.9% and Adv: 53.9%; p < 0.001); disease-free survival (DFS) (Fav: 57.8%, IM: 55.5% and Adv: 45.3; p < 0.001) and relapse (Fav: 28%, IM: 27.5% and Adv: 37.5%; p < 0.001). Multivariate analysis (MVA) revealed no differences in outcomes between the Fav and IM groups, thus they were combined. On MVA, patients in the Adv risk group had the highest risk of relapse (HR 1.47 p <= 0.001) and inferior DFS (HR 1.35 p < 0.001) and OS (HR 1.39 p < 0.001), even using myeloablative conditioning or in those without the pre-HCT measurable-residual disease. Novel approaches to mitigate relapse in this high-risk group are urgently needed.

引用

页码：3068 / 3077

页数：10

共 32 条

[1] Impact of detectable measurable residual disease on umbilical cord blood transplantation [J].

Baron, Frederic ;

Labopin, Myriam ;

Ruggeri, Annalisa ;

Sierra, Jorge ;

Robinson, Stephen ;

Labussiere-Wallet, Helene ;

Potter, Michael ;

Ribera, Josep-Maria ;

Deconinck, Eric ;

Rambaldi, Alessandro ;

Rohrlich, Pierre-Simon ;

de Revel, Thierry ;

Gluckman, Eliane ;

Nagler, Arnon ;

Mohty, Mohamad .

AMERICAN JOURNAL OF HEMATOLOGY, 2020, 95 (09) :1057-1065

[2] Validation of the 2017 European LeukemiaNet classification for acute myeloid leukemia with NPM1 and FLT3-internal tandem duplication genotypes [J].

Boddu, Prajwal C. ;

Kadia, Tapan M. ;

Garcia-Manero, Guillermo ;

Cortes, Jorge ;

Alfayez, Mansour ;

Borthakur, Gautam ;

Konopleva, Marina ;

Jabbour, Elias J. ;

Daver, Naval G. ;

DiNardo, Courtney D. ;

Naqvi, Kiran ;

Yilmaz, Musa ;

Short, Nicholas J. ;

Pierce, Sherry ;

Kantarjian, Hagop M. ;

Ravandi, Farhad .

CANCER, 2019, 125 (07) :1091-1100

[3] Prognostic index for adult patients with acute myeloid leukemia in first relapse [J].

Breems, DA ;

Van Putten, WLJ ;

Huijgens, PC ;

Ossenkoppele, GJ ;

Verhoef, GEG ;

Verdonck, LF ;

Vellenga, E ;

De Greef, G ;

Jacky, E ;

Van der Lelie, J ;

Boogaerts, MA ;

Löwenberg, B .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (09) :1969-1978

[4] Monosomal karyotype in acute myeloid leukemia:: A better indicator of poor prognosis than a complex karyotype [J].

Breems, Dimitri A. ;

Van Putten, Wim L. J. ;

De Greef, Georgine E. ;

Van Zelderen-Bhola, Shama L. ;

Gerssen-Schoorl, Klasien B. J. ;

Mellink, Clemens H. M. ;

Nieuwint, Aggie ;

Jotterand, Martine ;

Hagemeijer, Anne ;

Beverloo, H. Berna ;

Lowenberg, Bob .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (29) :4791-4797

[5] Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis [J].

Buckley, Sarah A. ;

Wood, Brent L. ;

Othus, Megan ;

Hourigan, Christopher S. ;

Ustun, Celalettin ;

Linden, Michael A. ;

DeFor, Todd E. ;

Malagola, Michele ;

Anthias, Chloe ;

Valkova, Veronika ;

Kanakry, Christopher G. ;

Gruhn, Bernd ;

Buccisano, Francesco ;

Devine, Beth ;

Walter, Roland B. .

HAEMATOLOGICA, 2017, 102 (05) :865-873

[6] Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia:: results from Cancer and Leukemia Group B (CALGB 8461) [J].

Byrd, JC ;

Mrózek, K ;

Dodge, RK ;

Carroll, AJ ;

Edwards, CG ;

Arthur, DC ;

Pettenati, MJ ;

Patil, SR ;

Rao, KW ;

Watson, MS ;

Koduru, PRK ;

Moore, JO ;

Stone, RM ;

Mayer, RJ ;

Feldman, EJ ;

Davey, FR ;

Schiffer, CA ;

Larson, RA ;

Bloomfield, CD .

BLOOD, 2002, 100 (13) :4325-4336

[7]

COX DR, 1972, J R STAT SOC B, V34, P187

[8] Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myeloid Leukemia: An Evidence-Based Review from the American Society of Transplantation and Cellular Therapy [J].

Dholaria, Bhagirathbhai ;

Savani, Bipin N. ;

Hamilton, Betty K. ;

Oran, Betul ;

Liu, Hien D. ;

Tallman, Martin S. ;

Ciurea, Stefan Octavian ;

Holtzman, Noa G. ;

Phillips, Gordon L., II ;

Devine, Steven M. ;

Mannis, Gabriel ;

Grunwald, Michael R. ;

Appelbaum, Frederick ;

Rodriguez, Cesar ;

El Chaer, Firas ;

Shah, Nina ;

Hashmi, Shahrukh K. ;

Kharfan-Dabaja, Mohamed A. ;

DeFilipp, Zachariah ;

Aljurf, Mahmoud ;

AlShaibani, AlFadel ;

Inamoto, Yoshihiro ;

Jain, Tania ;

Majhail, Navneet ;

Perales, Miguel-Angel ;

Mohty, Mohamad ;

Hamadani, Mehdi ;

Carpenter, Paul A. ;

Nagler, Arnon .

TRANSPLANTATION AND CELLULAR THERAPY, 2021, 27 (01) :6-20

[9] Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel [J].

Doehner, Hartmut ;

Estey, Elihu ;

Grimwade, David ;

Amadori, Sergio ;

Appelbaum, Frederick R. ;

Buechner, Thomas ;

Dombret, Herve ;

Ebert, Benjamin L. ;

Fenaux, Pierre ;

Larson, Richard A. ;

Levine, Ross L. ;

Lo-Coco, Francesco ;

Naoe, Tomoki ;

Niederwieser, Dietger ;

Ossenkoppele, Gert J. ;

Sanz, Miguel ;

Sierra, Jorge ;

Tallman, Martin S. ;

Tien, Hwei-Fang ;

Wei, Andrew H. ;

Lowenberg, Bob ;

Bloomfield, Clara D. .

BLOOD, 2017, 129 (04) :424-447

[10] Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet [J].

Doehner, Hartmut ;

Estey, Elihu H. ;

Amadori, Sergio ;

Appelbaum, Frederick R. ;

Buechner, Thomas ;

Burnett, Alan K. ;

Dombret, Herve ;

Fenaux, Pierre ;

Grimwade, David ;

Larson, Richard A. ;

Lo-Coco, Francesco ;

Naoe, Tomoki ;

Niederwieser, Dietger ;

Ossenkoppele, Gert J. ;

Sanz, Miguel A. ;

Sierra, Jorge ;

Tallman, Martin S. ;

Loewenberg, Bob ;

Bloomfield, Clara D. .

BLOOD, 2010, 115 (03) :453-474

← 1 2 3 4 →