Change in inflammatory parameters in prefrail and frail persons obtaining physical training and nutritional support provided by lay volunteers: A randomized controlled trial

被引:15
作者
Haider, Sandra [1 ]
Grabovac, Igor [1 ]
Winzer, Eva [1 ]
Kapan, Ali [1 ]
Schindler, Karin Emmi [2 ]
Lackinger, Christian [3 ]
Titze, Sylvia [4 ]
Dorner, Thomas Ernst [1 ]
机构
[1] Med Univ Vienna, Dept Social & Prevent Med, Ctr Publ Hlth, Vienna, Austria
[2] Med Univ Vienna, Div Endocrinol & Metab, Dept Internal Med 3, Vienna, Austria
[3] SPORTUNION, Dept Hlth Promot & Prevent, Vienna, Austria
[4] Karl Franzens Univ Graz, Inst Sport Sci, Graz, Austria
来源
PLOS ONE | 2017年 / 12卷 / 10期
关键词
C-REACTIVE PROTEIN; BIOELECTRICAL-IMPEDANCE ANALYSIS; APPENDICULAR SKELETAL-MUSCLE; NECROSIS-FACTOR-ALPHA; OLDER-ADULTS; BODY-COMPOSITION; GRIP STRENGTH; INTERLEUKIN-6; EXERCISE; MARKERS;
D O I
10.1371/journal.pone.0185879
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The aim of the study was to compare the effects of home visits with physical training and nutritional support on inflammatory parameters to home visits with social support alone within a randomized controlled trial. Prefrail and frail persons received home visits from lay volunteers twice a week for 12 weeks. Participants in the physical training and nutritional intervention group (PTN, n = 35) conducted two sets of six strength exercises and received nutritional support. The social support group (SoSu, n = 23) received visits only. TNF-alpha, IL-6, CRP, and total leukocyte count were assessed at baseline and after 12 weeks. Changes over time within groups were analyzed with paired t-tests; differences between groups were analyzed with ANCOVA for repeated measurements. In the PTN group, IL-6 and CRP remained stable, whereas in the SoSu group, IL-6 increased significantly from a median value of 2.6 pg/l (min-max = 2.0-10.2) to 3.0 pg/l (min-max = 2.0-20.8), and CRP rose from 0.2 mg/dl (min-max = 0.1-0.9) to 0.3 mg/dl (min-max = 0.1-3.0) after 12 weeks. In CRP, a significant difference between groups was found. TNF-a and total leukocyte count did not change in either the PTN group or the SoSu group. Persons showing an increase in physical performance (OR 4.54; 95% CI = 1.33-15.45) were more likely to have constant or decreased IL-6 values than persons who showed no improvement. In conclusion, in non-robust older adults, a physical training and nutritional support program provided by lay volunteers can delay a further increase in some inflammatory parameters.
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页数:16
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