Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review

被引：234

作者：

Mermer, Arif ^{[1
]}

Keles, Turgut ^{[2
]}

Sirin, Yakup ^{[3
]}

机构：

[1] Univ Hlth Sci Turkey, Expt Med Res & Applicat Ctr, TR-34662 Istanbul, Turkey

[2] Recep Tayyip Erdogan Univ, Cent Res Lab Applicat & Res Ctr, Rize, Turkey

[3] Baglarbasi Neighborhood, Adnan Kahveci St, Ankara, Turkey

来源：

BIOORGANIC CHEMISTRY | 2021年 / 114卷

关键词：

N-heterocyclic compound; Antiviral activity; Structure-activity relationship; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; INDOLE-DERIVATIVES; VIRUS; INHIBITORS; MICROWAVE; ANALOGS; DESIGN; DISCOVERY; HYBRIDS;

D O I：

10.1016/j.bioorg.2021.105076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-heterocycles are important, not only because of their abundance, but above all because of their chemical, biological and technical significance. They play an important role in biological investigation such as anticancer, antiinflammatory, antibacterial, antiviral, anti-tumor, antidiabetic, etc. In this study, we focused on examining synthesized some 5- or 6-ring N-heterocyclic compounds that showed the antiviral activity in last 5 years, and investigation of these compounds structure-activity relationship studies. This review will be useful to scientists in research fields of organic synthesis, medicinal chemistry, and pharmacology.

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页数：48

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