Biological functions of MicroRNAs

被引：50

作者：

Huang, Yong ^{[1
]}

Shen, Xing Jia ^{[1
,2
]}

Zou, Quan ^{[3
]}

Zhao, Qiao Ling ^{[1
,2
]}

机构：

[1] Jiang Su Univ Sci & Technol, Zhenjiang 212018, Jiangsu, Peoples R China

[2] Chinese Acad Agr Sci, Key Lab Silkworm & Mulberry Genet Improvement, Minist Agr, Sericultural Res Inst, Zhenjiang 212018, Jiangsu, Peoples R China

[3] Xiamen Univ, Sch Informat Sci & Technol, Xiamen 361005, Fujian, Peoples R China

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2010年 / 36卷 / 06期

关键词：

microRNA; biogenesis; function; expression; diseases; NEURONAL DIFFERENTIATION; CELL-DIFFERENTIATION; EXPRESSION; RNA; MODULATION; PROTEIN; IDENTIFICATION; BIOGENESIS; HEPATITIS; ELEGANS;

D O I：

10.1134/S1068162010060026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The small regulatory non-coding RNA molecules, known as microRNAs (miRNAs), have been recognized as potential regulator of gene expression and modulate the gene function at the post-transcriptional level. It is now clear that miRNA biogenesis and function are related to the molecular mechanisms of various clinical diseases, which can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death viral infection and tumorgenesis. Here, we review recent work and provide insight into the diverse roles of miRNAs.

引用

页码：684 / 689

页数：6

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