Direct C-H Arylation and Alkylation of Electron-Deficient Heteroaromatic Compounds with Organozinc Reagents

被引：1

作者：

Peng, Zhihua ^{[1
]}

Yu, Chuanman ^{[1
]}

Wang, Yilei ^{[1
]}

Wei, Dongyue ^{[1
]}

Jiang, Cuiyu ^{[1
]}

机构：

[1] China Univ Petr East China, Dept Chem, Coll Sci, Qingdao 266580, Shandong, Peoples R China

来源：

ORGANOMETALLICS | 2021年 / 40卷 / 21期

关键词：

CATALYZED DIRECT ARYLATION; N-HETEROARENES; ARYLZINC REAGENTS; BOND ARYLATION; FUNCTIONALIZATION; PYRIDINE; IRON; HETEROCYCLES; MAGNESIUM; COBALT;

D O I：

10.1021/acs.organomet.1c00505

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A direct and convenient method for the C-H arylation and alkylation of electron-deficient N-heteroarenes with readily available organozinc reagents has been developed. This transformation could be readily performed in the absence of a transition-metal catalyst and external oxidants, affording a wide range of substituted heteroarenes with good functional group tolerance in good to excellent yields. The developed simple protocol is scalable to the gram level and suitable for late-stage modification of bioactive molecules and drugs.

引用

页码：3678 / 3688

页数：11

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