In vitro effects of alloxan-vanadium combination on lipid peroxidation and on antioxidant enzyme activity

被引：8
|
作者：
Alexandrova, A [1 ]
Kirkova, M [1 ]
Russanov, E [1 ]
机构：
[1] Bulgarian Acad Sci, Inst Physiol, BU-1113 Sofia, Bulgaria
来源：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1998年 / 31卷 / 03期
关键词：
alloxan; dialuric acid; vanadium ions; lipid peroxidation; antioxidant enzyme activity;
D O I：
10.1016/S0306-3623(97)00452-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The in vitro effects of alloxan, dialuric acid and vanadium ions, alone or in combination, on lipid peroxidation and on antioxidant enzyme activity in rat liver and kidney were studied. 2. Unlike alloxan, alloxan-glutathione (GSH) and dialuric acid increased lipid peroxidation, which could be explained by the decreased activity of catalase and GSH peroxidase during incubation. 3. Vanadium(IV) ions increased the amount of thiobarbituric acid reacting substances, but neither vanadium(IV) nor vanadium(V) changed the enzyme activity. 4. The combination of vanadium ions and alloxan-GSH or dialuric acid had no additive effect on lipid peroxidation. Vanadium ions decreased the dialuric acid induced inhibition of catalase activity. 5. The present results suggest the therapeutic value of vanadium as an antidiabetic agent. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：489 / 493
页数：5
相关论文
共 50 条
  • [21] LIPID-PEROXIDATION AND ANTIOXIDANT ENZYME-ACTIVITY IN ASPIRIN-TREATED RATS
    KIRKOVA, M
    IVANCHEVA, E
    RUSSANOV, E
    GENERAL PHARMACOLOGY, 1995, 26 (03): : 613 - 617
  • [22] Dynamics of Lipid Peroxidation—Antioxidant Defense System during Alloxan Diabetes in Rats
    I. A. Volchegorskii
    L. M. Rassokhina
    I. Yu. Miroshnichenko
    Bulletin of Experimental Biology and Medicine, 2013, 155 : 26 - 29
  • [23] Effects of methomyl on lipid peroxidation and antioxidant enzymes in rat erythrocytes: In vitro studies
    Mansour, Sameeh A.
    Mossa, Abdel-Tawab H.
    Heikal, Tarek M.
    TOXICOLOGY AND INDUSTRIAL HEALTH, 2009, 25 (08) : 557 - 563
  • [24] Lipid peroxidation and antioxidant activity in complicated pregnancies
    Patil, S. B.
    Kodliwadmath, M. V.
    Kodliwadmath, S. M.
    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 2009, 36 (02): : 110 - 112
  • [25] Comparative study of alloxan effects in copper-loaded and iron-loaded rats: lipid peroxidation, protein oxidation, proteasome and antioxidant enzyme activities
    Alexandrova, Albena
    Georgieva, Almira
    Petrov, Lubomir
    Tsvetanova, Elina
    Kirkova, Margarita
    CENTRAL EUROPEAN JOURNAL OF BIOLOGY, 2006, 1 (02): : 235 - 248
  • [26] Antioxidant enzyme activity and lipid peroxidation in the blood of rats co-treated with vanadium (V+5) and chromium (Cr+3)
    Scibior, Agnieszka
    Zaporowska, Halina
    Wolinska, Agnieszka
    Ostrowski, Jaroslaw
    CELL BIOLOGY AND TOXICOLOGY, 2010, 26 (06) : 509 - 526
  • [27] Antioxidant enzyme activity and lipid peroxidation in the blood of rats co-treated with vanadium (V+5) and chromium (Cr+3)
    Agnieszka Ścibior
    Halina Zaporowska
    Agnieszka Wolińska
    Jarosław Ostrowski
    Cell Biology and Toxicology, 2010, 26 : 509 - 526
  • [28] Effects of salt on lipid peroxidation and antioxidant enzyme activities of Catharanthus roseus suspension cells
    Elkahoui, S
    Hernández, JA
    Abdelly, C
    Ghrir, R
    Limam, F
    PLANT SCIENCE, 2005, 168 (03) : 607 - 613
  • [29] Effects of antihypertensive drugs on rat tissue antioxidant enzyme activities and lipid peroxidation levels
    Cabell, KS
    Ma, L
    Johnson, P
    BIOCHEMICAL PHARMACOLOGY, 1997, 54 (01) : 133 - 141
  • [30] A SIMPLE LUMINESCENCE METHOD FOR DETECTING LIPID-PEROXIDATION AND ANTIOXIDANT ACTIVITY IN-VITRO
    NAKANO, M
    ITO, T
    ARIMOTO, T
    USHIJIMA, Y
    KAMIYA, K
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 202 (02) : 940 - 946
12345