Acceleration under solvent-drop grinding: Synthesis of bis(indolyl) methanes using small amounts of organic solvents or ionic liquids

被引：10

作者：

Tanemura, Kiyoshi ^{[1
]}

机构：

[1] Nippon Dent Univ, Sch Life Dent Niigata, Chem Lab, Hamaura, Niigata 9518580, Japan

来源：

TETRAHEDRON LETTERS | 2021年 / 82卷

关键词：

Solvent-drop grinding; Solvent effect; Bis(indolyl)methanes; Ionic liquids; BIS-INDOLYL METHANE; SILICA-GEL; HETEROGENEOUS CATALYST; CONVENIENT SYNTHESIS; MICHAEL ADDITION; SOLID-STATE; EFFICIENT; ACID; WATER; CONDENSATION;

D O I：

10.1016/j.tetlet.2021.153391

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions for the synthesis of bis(indolyl)methanes were accelerated by the addition of a few drops of solvents. Solvent effect for the addition of organic solvents and ionic liquids was examined. The yields of bis(indolyl)methanes increased by the addition of THF, 1-ethyl-3-ethylimidazolium bis(trifluoromethylsulfonyl)imide ([emim]NTf2), and 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim]PF6). Solvent-drop grinding methodology was quite useful for the reactions of "solid + liquid" as well as "solid + solid". (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：9

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