Programmable biomaterials for dynamic and responsive drug delivery

被引：10

作者：

Stejskalova, Anna ^{[1
]}

Kiani, Mehrdad T. ^{[1
]}

Almquist, Benjamin D. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2AZ, England

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 241卷 / 10期

关键词：

Bionanoscience; biomaterials; drug delivery; cancer; bacteria; nanoparticles; FREE CLICK CHEMISTRY; IN-VIVO; CELL-ADHESION; ANTIBIOTIC-RESISTANCE; MOLECULAR BEACONS; DENDRITIC CELLS; APTAMER; CANCER; SIRNA; NANOPARTICLES;

D O I：

10.1177/1535370216649445

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Biomaterials are continually being designed that enable new methods for interacting dynamically with cell and tissues, in turn unlocking new capabilities in areas ranging from drug delivery to regenerative medicine. In this review, we explore some of the recent advances being made in regards to programming biomaterials for improved drug delivery, with a focus on cancer and infection. We begin by explaining several of the underlying concepts that are being used to design this new wave of drug delivery vehicles, followed by examining recent materials systems that are able to coordinate the temporal delivery of multiple therapeutics, dynamically respond to changing tissue environments, and reprogram their bioactivity over time.

引用

页码：1127 / 1137

页数：11

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