Hemophagocytic Lymphohistiocytosis Associated With Hemolytic Uremic Syndrome in a Child: A Case Report and Systematic Literature Review

被引：2

作者：

Tas, Nesrin ^{[1
]}

Gokceoglu, Arife U. ^{[1
]}

Yayla, Burcu C. C. ^{[2
]}

Ozcan, Aysegul ^{[3
]}

Sac, Rukiye U. ^{[4
]}

Vezir, Emine ^{[5
]}

Alioglu, Bulent ^{[6
]}

机构：

[1] Univ Hlth Sci Ankara Training & Res Hosp, Dept Pediat Nephrol, Ankara, Turkey

[2] Univ Hlth Sci Ankara Training & Res Hosp, Dept Pediat Infect Dis, Ankara, Turkey

[3] Univ Hlth Sci Ankara Training & Res Hosp, Dept Genet, Ankara, Turkey

[4] Univ Hlth Sci Ankara Training & Res Hosp, Dept Gen Pediat, Ankara, Turkey

[5] Univ Hlth Sci Ankara Training & Res Hosp, Dept Allergy & Immunol, Ankara, Turkey

[6] Univ Hlth Sci Ankara Training & Res Hosp, Dept Hematol, Ankara, Turkey

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2022年 / 44卷 / 05期

关键词：

hemolytic-uremic syndrome; lymphohistiocytosis; hemophagocytic; anemia; hemolytic; hepatomegaly; splenomegaly; MACROPHAGE ACTIVATION SYNDROME; THROMBOTIC MICROANGIOPATHY; INFECTION; DISEASE; FEVER;

D O I：

10.1097/MPH.0000000000002265

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder resulting from excessive activation and nonmalignant proliferation of T-lymphocytes and macrophages. Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Reports pertaining to the association between HLH and HUS are rarely published; however, we report on a 4-year-old boy who was diagnosed with both conditions and treated successfully with high-dose steroid and intravenous immunoglobulin. Differentiating HUS from HLH can be challenging because of their clinical similarities. Therefore, prompt diagnosis and immunosuppressive treatment are essential and life-saving to these patients.

引用

页码：E905 / E910

页数：6

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