Favorable outcomes for allogeneic hematopoietic cell transplantation in elderly patients with NPM1-mutated and FLT3-ITD-negative acute myeloid leukemia

被引:13
作者
Aldoss, Ibrahim [1 ]
Nakamura, Ryotaro [1 ]
Yang, Dongyun [2 ]
Salhotra, Amandeep [1 ]
Stein, Anthony S. [1 ]
Pullarkat, Vinod [1 ]
Forman, Stephen J. [1 ]
Marcucci, Guido [1 ]
机构
[1] Gehr Family Ctr Leukemia Res, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA 91010 USA
[2] City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Duarte, CA USA
关键词
NPM1; MUTATIONS; PROGNOSTIC IMPACT; ADULT PATIENTS; NUCLEOPHOSMIN; OLDER;
D O I
10.1038/s41409-019-0553-x
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:473 / 475
页数:3
相关论文
共 9 条
  • [1] Favorable Prognostic Impact of NPM1 Mutations in Older Patients With Cytogenetically Normal De Novo Acute Myeloid Leukemia and Associated Gene- and MicroRNA-Expression Signatures: A Cancer and Leukemia Group B Study
    Becker, Heiko
    Marcucci, Guido
    Maharry, Kati
    Radmacher, Michael D.
    Mrozek, Krzysztof
    Margeson, Dean
    Whitman, Susan P.
    Wu, Yue-Zhong
    Schwind, Sebastian
    Paschka, Peter
    Powell, Bayard L.
    Carter, Thomas H.
    Kolitz, Jonathan E.
    Wetzler, Meir
    Carroll, Andrew J.
    Baer, Maria R.
    Caligiuri, Michael A.
    Larson, Richard A.
    Bloomfield, Clara D.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (04) : 596 - 604
  • [2] Age-Related Risk Profile and Chemotherapy Dose Response in Acute Myeloid Leukemia: A Study by the German Acute Myeloid Leukemia Cooperative Group
    Buechner, Thomas
    Berdel, Wolfgang E.
    Haferlach, Claudia
    Haferlach, Torsten
    Schnittger, Susanne
    Mueller-Tidow, Carsten
    Braess, Jan
    Spiekermann, Karsten
    Kienast, Joachim
    Staib, Peter
    Grueneisen, Andreas
    Kern, Wolfgang
    Reichle, Albrecht
    Maschmeyer, Georg
    Aul, Carlo
    Lengfelder, Eva
    Sauerland, Maria-Cristina
    Heinecke, Achim
    Woermann, Bernhard
    Hiddemann, Wolfgang
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (01) : 61 - 69
  • [3] Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
    Doehner, Hartmut
    Estey, Elihu
    Grimwade, David
    Amadori, Sergio
    Appelbaum, Frederick R.
    Buechner, Thomas
    Dombret, Herve
    Ebert, Benjamin L.
    Fenaux, Pierre
    Larson, Richard A.
    Levine, Ross L.
    Lo-Coco, Francesco
    Naoe, Tomoki
    Niederwieser, Dietger
    Ossenkoppele, Gert J.
    Sanz, Miguel
    Sierra, Jorge
    Tallman, Martin S.
    Tien, Hwei-Fang
    Wei, Andrew H.
    Lowenberg, Bob
    Bloomfield, Clara D.
    [J]. BLOOD, 2017, 129 (04) : 424 - 447
  • [4] Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics:: interaction with other gene mutations
    Döhner, K
    Schlenk, RF
    Habdank, M
    Scholl, C
    Rücker, FG
    Corbacioglu, A
    Bullinger, L
    Fröhling, S
    Döhner, H
    [J]. BLOOD, 2005, 106 (12) : 3740 - 3746
  • [5] Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
    Falini, B
    Mecucci, C
    Tiacci, E
    Alcalay, M
    Rosati, R
    Pasqualucci, L
    La Starza, R
    Diverio, D
    Colombo, E
    Santucci, A
    Bigerna, B
    Pacini, R
    Pucciarini, A
    Liso, A
    Vignetti, M
    Fazi, P
    Meani, N
    Pettirossi, V
    Saglio, G
    Mandelli, F
    Lo-Coco, F
    Pelicci, P
    Martelli, MF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (03) : 254 - 266
  • [6] The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    Gale, Rosemary E.
    Green, Claire
    Allen, Christopher
    Mead, Adam J.
    Burnett, Alan K.
    Hils, Robert K.
    Linch, David C.
    [J]. BLOOD, 2008, 111 (05) : 2776 - 2784
  • [7] Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    Schlenk, Richard F.
    Doehner, Konstanze
    Krauter, Juergen
    Froehling, Stefan
    Corbacioglu, Andrea
    Bullinger, Lars
    Habdank, Marianne
    Spaeth, Daniela
    Morgan, Michael
    Benner, Axel
    Schlegelberger, Brigitte
    Heil, Gerhard
    Ganser, Arnold
    Doehner, Hartmut
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (18) : 1909 - 1918
  • [8] Clinical impact of nucleophosmin mutations and Flt3 internal tandem duplications in patients older than 60 yr with acute myeloid leukaemia
    Scholl, Sebastian
    Theuer, Claudia
    Scheble, Veit
    Kunert, Christa
    Heller, Anita
    Muegge, Lars-Olof
    Fricke, Hans-Joerg
    Hoeffken, Klaus
    Wedding, Ulrich
    [J]. EUROPEAN JOURNAL OF HAEMATOLOGY, 2008, 80 (03) : 208 - 215
  • [9] Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    Thiede, Christian
    Koch, Sina
    Creutzig, Eva
    Steudel, Christine
    Illmer, Thomas
    Schaich, Markus
    Ehninger, Gerhard
    [J]. BLOOD, 2006, 107 (10) : 4011 - 4020