Functional Analysis of Long Noncoding RNAs in Development and Disease

被引：72

作者：

Chen, Ling-Ling ^{[1
]}

Zhao, Jing Crystal ^{[2
]}

机构：

[1] Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China

[2] Sanford Burnham Med Res Inst, RNA Biol Program, La Jolla, CA 92037 USA

来源：

SYSTEMS BIOLOGY OF RNA BINDING PROTEINS | 2014年 / 825卷

基金：

中国国家自然科学基金;

关键词：

Epigenetics; Long noncoding RNA; Xist; sno-lncRNA; Cancer; RIP-seq; CLIP-seq; Chart; ChIRP; X-CHROMOSOME INACTIVATION; GENOME-WIDE IDENTIFICATION; H3; LYSINE-27; METHYLATION; PRADER-WILLI-SYNDROME; EMBRYONIC STEM-CELLS; XIST RNA; BINDING PROTEIN; GENE-EXPRESSION; A-REPEAT; METHYLTRANSFERASE ACTIVITY;

D O I：

10.1007/978-1-4939-1221-6_4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Once viewed as part of the "dark matter" of genome, long noncoding RNAs (lncRNAs), which are mRNA-like but lack open reading frames, have emerged as an integral part of the mammalian transcriptome. Recent work demonstrated that lncRNAs play multiple structural and functional roles, and their analysis has become a new frontier in biomedical research. In this chapter, we provide an overview of different lncRNA families, describe methodologies available to study lncRNA-protein and lncRNA-DNA interactions systematically, and use well-studied lncRNAs as examples to illustrate their functional importance during normal development and in disease states.

引用

页码：129 / 158

页数：30

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