Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review

被引：143

作者：

Bjornstad, Petter ^{[1
,2
]}

Eckel, Robert H. ^{[3
,4
]}

机构：

[1] Univ Colorado, Sch Med, Dept Pediat, Div Endocrinol, 13123 East 16th Ave,Box B26, Aurora, CO 80045 USA

[2] Univ Colorado, Sch Med, Dept Med, Div Renal Dis & Hypertens, Aurora, CO 80045 USA

[3] Univ Colorado, Sch Med, Dept Med, Div Endocrinol, Aurora, CO 80045 USA

[4] Univ Colorado, Sch Med, Div Cardiol, Aurora, CO 80045 USA

来源：

CURRENT DIABETES REPORTS | 2018年 / 18卷 / 12期

关键词：

Insulin resistance; Dyslipidemia; Hypertriglyceridemia; CORONARY-ARTERY CALCIFICATION; TYPE-1; DIABETES-MELLITUS; SUBFRACTION CHOLESTEROL DISTRIBUTION; DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR-DISEASE RISK; ACTIVATED PROTEIN-KINASE; TODAY CLINICAL-TRIAL; FATTY LIVER-DISEASE; GLYCEMIC CONTROL; ATHEROSCLEROTIC PLAQUES;

D O I：

10.1007/s11892-018-1101-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of reviewInsulin resistance (IR) is recognized to play an important role in the pathogenesis of dyslipidemia. This review summarizes the complex interplay between IR and dyslipidemia in people with and without diabetes.Recent findingsIR impacts the metabolism of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C) by several mechanisms. Trials with insulin sensitizing therapies, including biguanides and thiazolidinediones, have provided inconsistent results on lipid lowering in people with and without diabetes. In this review, we focus on the pathophysiological interplay between IR and dyslipidemia and recapitulate lipid and lipoprotein data from insulin-sensitizing trials.SummaryFurther research elucidating the reciprocal relationship between IR and dyslipidemia is needed to better target these important risk factors for cardiovascular disease.

引用

页数：8

共 114 条

[91] Characterization of 33 488 children and adolescents with type 1 diabetes based on the gender-specific increase of cardiovascular risk factors [J].

Schwab, K. Otfried ;

Doerfer, Juergen ;

Marg, Wolfgang ;

Schober, Edith ;

Holl, Reinhard W. .

PEDIATRIC DIABETES, 2010, 11 (05) :357-363

[92] Spectrum and prevalence of atherogenic risk factors in 27,358 children, adolescents, and young adults with type 1 diabetes [J].

Schwab, KO ;

Doerfer, J ;

Hecker, W ;

Grulich-Henn, J ;

Wiemann, D ;

Kordonouri, O ;

Beyer, P ;

Holl, RW .

DIABETES CARE, 2006, 29 (02) :218-225

[93] Electrocardiographic Abnormalities and Cardiovascular Disease Risk in Type 1 Diabetes: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study [J].

Soliman, Elsayed Z. ;

Backlund, Jye-Yu C. ;

Bebu, Ionut ;

Orchard, Trevor J. ;

Zinman, Bernard ;

Lachin, John M. .

DIABETES CARE, 2017, 40 (06) :793-799

[94]

Sonne DP, 2015, DIABETES CARE, V38, P1858, DOI DOI 10.2337/dc15-0658

[95] RELATIONSHIPS BETWEEN RISK-FACTORS AND MORPHOLOGICAL PATTERNS OF HUMAN CAROTID ATHEROSCLEROTIC PLAQUES - A MULTIVARIATE DISCRIMINANT-ANALYSIS [J].

SPAGNOLI, LG ;

MAURIELLO, A ;

PALMIERI, G ;

SANTEUSANIO, G ;

AMANTE, A ;

TAURINO, M .

ATHEROSCLEROSIS, 1994, 108 (01) :39-60

[96] Selective Hepatic Insulin Resistance, VLDL Overproduction, and Hypertriglyceridemia [J].

Sparks, Janet D. ;

Sparks, Charles E. ;

Adeli, Khosrow .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (09) :2104-2112

[97] Estimated Insulin Sensitivity and Cardiovascular Disease Risk Factors in Adolescents with and without Type 1 Diabetes [J].

Specht, Brian J. ;

Wadwa, R. Paul ;

Snell-Bergeon, Janet K. ;

Nadeau, Kristen J. ;

Bishop, Franziska K. ;

Maahs, David M. .

JOURNAL OF PEDIATRICS, 2013, 162 (02) :297-301

[98] AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases [J].

Srivastava, Rai Ajit K. ;

Pinkosky, Stephen L. ;

Filippov, Sergey ;

Hanselman, Jeffrey C. ;

Cramer, Clay T. ;

Newton, Roger S. .

JOURNAL OF LIPID RESEARCH, 2012, 53 (12) :2490-2514

[99] Insulin pump therapy, multiple daily injections, and cardiovascular mortality in 18 168 people with type 1 diabetes: observational study [J].

Steineck, Isabelle ;

Cederholm, Jan ;

Eliasson, Bjorn ;

Rawshani, Araz ;

Eeg-Olofsson, Katarina ;

Svensson, Ann-Marie ;

Zethelius, Bjorn ;

Avdic, Tarik ;

Landin-Olsson, Mona ;

Jendle, Johan ;

Gudbjornsdottir, Soffia .

BMJ-BRITISH MEDICAL JOURNAL, 2015, 350

[100]

TAKAYAMA S, 1988, J BIOL CHEM, V263, P3440

← 3 4 5 6 7 8 9 10 11 12 →