Direct palladium-catalyzed alkynylation of N-fused heterocycles

被引：253

作者：

Seregin, Ilya V. ^{[1
]}

Ryabova, Victoria ^{[1
]}

Gevorgyan, Vladimir ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 25期

关键词：

D O I：

10.1021/ja072718l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of direct C-H alkynylation of electron-rich heteroaromatics has been demonstrated. This mild, simple, and general method allows for the efficient synthesis of diverse alkynyl heterocycles. Kinetic isotope effect studies support an electrophilic substitution pathway for this transformation.

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页码：7742 / +

页数：3

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