Clinical adaptation of synthetic MRI-based whole brain volume segmentation in children at 3 T: comparison with modified SPM segmentation methods

被引：5

作者：

Lee, So Mi ^{[1
,2
]}

Kim, Eunji ^{[3
]}

You, Sun Kyoung ^{[4
]}

Cho, Hyun-Hae ^{[5
,6
]}

Hwang, Moon Jung ^{[7
]}

Hahm, Myong-Hun ^{[1
,2
]}

Cho, Seung Hyun ^{[1
,2
]}

Kim, Won Hwa ^{[1
,2
]}

Kim, Hye Jung ^{[1
,2
]}

Shin, Kyung Min ^{[1
,2
]}

Park, Byunggeon ^{[1
,2
]}

Chang, Yongmin ^{[8
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea

[2] Kyungpook Natl Univ, Dept Radiol, Chilgok Hosp, Daegu, South Korea

[3] Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu, South Korea

[4] Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Radiol, Coll Med, Daejeon, South Korea

[5] Ewha Womans Univ, Coll Med, Dept Radiol, Anyangcheon Ro 1071, Seoul 07985, South Korea

[6] Ewha Womans Univ, Coll Med, Med Res Inst, Anyangcheon Ro 1071, Seoul 07985, South Korea

[7] Gen Elect GE Healthcare Korea, Seoul, South Korea

[8] Kyungpook Natl Univ, Sch Med, Dept Mol Med, 130 Dongdeok Ro, Daegu 41944, South Korea

来源：

NEURORADIOLOGY | 2022年 / 64卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Synthetic MRI; SPM; Children; Brain segmentation; Multispectral segmentation; INTRACRANIAL VOLUME; TISSUE; QUANTIFICATION; IMAGES;

D O I：

10.1007/s00234-021-02779-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose To validate the use of synthetic magnetic resonance imaging (SyMRI) volumetry by comparing with child-optimized SPM 12 volumetry in 3 T pediatric neuroimaging. Methods In total, 106 children aged 4.7-18.7 years who underwent both synthetic and 3D T1-weighted imaging and had no abnormal imaging/neurologic findings were included for the SyMRI vs. SPM T1-only segmentation (SPM T1). Forty of the 106 children who underwent an additional 3D T2-weighted imaging were included for the SyMRI vs. SPM multispectral segmentation (SPM multi). SPM segmentation using an age-appropriate atlas and inverse-transforming template-space intracranial mask was compared with SyMRI segmentation. Volume differences between SyMRI and SPM T1 were plotted against age to evaluate the influence of age on volume difference. Results Measurements derived from SyMRI and two SPM methods showed excellent agreements and strong correlations except for the CSF volume (CSFV) (intraclass correlation coefficients = 0.87-0.98; r = 0.78-0.96; relative volume difference other than CSFV = 6.8-18.5% [SyMRI vs. SPM T1] and 11.3-22.7% [SyMRI vs. SPM multi]). Dice coefficients of all brain tissues (except CSF) were in the range 0.78-0.91. The Bland-Altman plot and age-related volume difference change suggested that the volume differences between the two methods were influenced by the volume of each brain tissue and subject's age (p < 0.05). Conclusion SyMRI and SPM segmentation results were consistent except for CSFV, which supports routine clinical use of SyMRI-based volumetry in pediatric neuroimaging. However, caution should be taken in the interpretation of the CSF segmentation results.

引用

页码：381 / 392

页数：12

共 35 条

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