Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis

被引：11

作者：

Bronzi Guimaraes, Fabio Augusto ^{[1
]}

de Oliveira-Cardoso, Erika Arantes ^{[1
,2
]}

Mastropietro, Ana Paula ^{[3
]}

Voltarelli, Julio Cesar ^{[4
]}

dos Santos, Manoel Antonio ^{[5
]}

机构：

[1] Univ Sao Paulo, Dept Psicol & Educ, Fac Filosofia Ciencias & Letras, BR-14040901 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Sch Med Ribeirao Preto,Clin Hosp, Bone Marrow Transplant Unit, Postgrad Program Psychol,Fac Philosophy Sci & Let, BR-14040901 Ribeirao Preto, Brazil

[3] Clin Hosp, Sch Med Ribeirao Preto, Occupat Therapy Serv, Postgrad Program Psychol, Ribeirao Preto, Brazil

[4] Clin Hosp, Sch Med Ribeirao Preto, Bone Marrow Transplant Unit, Ribeirao Preto, Brazil

[5] Univ Sao Paulo, Inst Psychol, Postgraduat Program Psychol, BR-14040901 Ribeirao Preto, SP, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2010年 / 68卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

quality of life; multiple sclerosis; bone marrow transplantation; FOLLOW-UP; DISABILITY; FATIGUE; DEPRESSION;

D O I：

10.1590/S0004-282X2010000400009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. Method: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of Sao Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. Results: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. Conclusion: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life.

引用

页码：522 / 527

页数：6

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[31] Autologous hemopoietic stem cell transplantation for multiple sclerosis: Is it worthwile? [J].

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