Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis

被引：11
作者：
Bronzi Guimaraes, Fabio Augusto [1 ]
de Oliveira-Cardoso, Erika Arantes [1 ,2 ]
Mastropietro, Ana Paula [3 ]
Voltarelli, Julio Cesar [4 ]
dos Santos, Manoel Antonio [5 ]
机构：
[1] Univ Sao Paulo, Dept Psicol & Educ, Fac Filosofia Ciencias & Letras, BR-14040901 Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto,Clin Hosp, Bone Marrow Transplant Unit, Postgrad Program Psychol,Fac Philosophy Sci & Let, BR-14040901 Ribeirao Preto, Brazil
[3] Clin Hosp, Sch Med Ribeirao Preto, Occupat Therapy Serv, Postgrad Program Psychol, Ribeirao Preto, Brazil
[4] Clin Hosp, Sch Med Ribeirao Preto, Bone Marrow Transplant Unit, Ribeirao Preto, Brazil
[5] Univ Sao Paulo, Inst Psychol, Postgraduat Program Psychol, BR-14040901 Ribeirao Preto, SP, Brazil
来源：
ARQUIVOS DE NEURO-PSIQUIATRIA | 2010年 / 68卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
quality of life; multiple sclerosis; bone marrow transplantation; FOLLOW-UP; DISABILITY; FATIGUE; DEPRESSION;
D O I：
10.1590/S0004-282X2010000400009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Objective: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. Method: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of Sao Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. Results: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. Conclusion: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life.
引用
收藏
页码：522 / 527
页数：6
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