Time and the Metrics of Aging

被引：177

作者：

Ferrucci, Luigi ^{[1
]}

Levine, Morgan E. ^{[2
]}

Kuo, Pei-Lun ^{[1
,3
]}

Simonsick, Eleanor M. ^{[1
]}

机构：

[1] NIA, Longitudinal Studies Sect, Translat Gerontol Branch, Baltimore, MD 21224 USA

[2] Yale Sch Med, Dept Pathol, New Haven, CT USA

[3] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

CIRCULATION RESEARCH | 2018年 / 123卷 / 07期

关键词：

aging; frailty; geriatrics; geroscience; health span; humans; DISEASE; AUTOPHAGY; CELLS;

D O I：

10.1161/CIRCRESAHA.118.312816

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The study of aging relates to changes in physical and functional dimensions that occur over time in living organisms. Yet, a model that establishes the hierarchical relationship and interlaced time courses of molecular, phenotypic, and functional hierarchical domains of aging in humans has not been established. We propose that studying the mechanisms and consequences of aging through the lens of these hierarchical domains and their connections will provide clarity in semantics and enhance a translational perspective. The study of human aging would be the most informative from a life course, longitudinal perspective, given that manifestations of aging are already detectable early in life at the molecular level, yet the phenotypic responses remain masked by compensatory/resiliency mechanisms. Understanding the nature of these mechanisms is paramount for developing interventions that reduce the burden of disease and disability in older people.

引用

页码：740 / 744

页数：5

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